Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality?
Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality?
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DOI：
10.3390/ijms22157824
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发表时间：
2021-07-22
影响因子：
5.6
通讯作者：
Tanaka J
中科院分区：
文献类型：
--
作者：
Choudhury ME;Miyanishi K;Takeda H;Tanaka J
睡眠质量差和昼夜节律行为紊乱是衰老的正常部分，包括白天过度困倦，睡眠碎片增加，总睡眠时间和睡眠质量下降。尽管睡眠不良的细胞机制背后的神经元衰退已经被广泛研究，但大脑功能并不完全依赖于神经元。最近对老年人脑进行的生前自拍研究和死后RNA测序及免疫组织化学研究，探讨了睡眠片断与脑内天然免疫细胞--小胶质细胞激活的关系。在衰老过程中，脑内小胶质细胞数量明显减少，小胶质细胞的耗竭扰乱了脑组织的昼夜节律。在之前的一项研究中，我们还表明，药物抑制小胶质功能会导致睡眠异常。然而，小胶质细胞对睡眠稳态的作用机制才刚刚开始被理解。这篇综述回顾了衰老对小胶质细胞数量和激活的影响，以及小胶质细胞对睡眠维持和对睡眠丧失的反应的贡献。最重要的是，这篇综述将回答一些问题，如衰老的小胶质细胞与年龄相关的低质量睡眠之间是否存在联系，以及这如何加剧神经退行性疾病。
Poor sleep quality and disrupted circadian behavior are a normal part of aging and include excessive daytime sleepiness, increased sleep fragmentation, and decreased total sleep time and sleep quality. Although the neuronal decline underlying the cellular mechanism of poor sleep has been extensively investigated, brain function is not fully dependent on neurons. A recent antemortem autographic study and postmortem RNA sequencing and immunohistochemical studies on aged human brain have investigated the relationship between sleep fragmentation and activation of the innate immune cells of the brain, microglia. In the process of aging, there are marked reductions in the number of brain microglial cells, and the depletion of microglial cells disrupts circadian rhythmicity of brain tissue. We also showed, in a previous study, that pharmacological suppression of microglial function induced sleep abnormalities. However, the mechanism underlying the contribution of microglial cells to sleep homeostasis is only beginning to be understood. This review revisits the impact of aging on the microglial population and activation, as well as microglial contribution to sleep maintenance and response to sleep loss. Most importantly, this review will answer questions such as whether there is any link between senescent microglia and age-related poor quality sleep and how this exacerbates neurodegenerative disease.
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DOI：
10.1523/jneurosci.1423-10.2010
发表时间：
2010-06-30
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dworak M;McCarley RW;Kim T;Kalinchuk AV;Basheer R
通讯作者：
Basheer R
影响因子：
5.6
作者：
Choudhury ME;Kigami Y;Tanaka J
通讯作者：
Tanaka J
影响因子：
4.2
作者：
Banks G;Heise I;Starbuck B;Osborne T;Wisby L;Potter P;Jackson IJ;Foster RG;Peirson SN;Nolan PM
通讯作者：
Nolan PM
影响因子：
5.3
作者：
Costa, Jessica;Martins, Solange;Cardoso, Ana L.
通讯作者：
Cardoso, Ana L.
影响因子：
2.1
作者：
Abel, Magdalena;Baeuml, Karl-Heinz T.
通讯作者：
Baeuml, Karl-Heinz T.