"Ménage à Trois": the evolutionary interplay between JSRV, enJSRVs and domestic sheep.
"Ménage à Trois": the evolutionary interplay between JSRV, enJSRVs and domestic sheep.
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DOI：
10.3390/v6124926
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发表时间：
2014-12-09
期刊：
影响因子：
--
通讯作者：
Arnaud F
中科院分区：
文献类型：
--
作者：
Armezzani A;Varela M;Spencer TE;Palmarini M;Arnaud F
绵羊β逆转录病毒是研究自然环境中宿主和病原体之间复杂进化相互作用的一个有趣模型。在感染的绵羊中，外源性和致病性绵羊肺腺瘤病毒（JSRV）与多种高度相关的内源性JSRV共存，称为enJSRVs。在进化过程中，它们中的一些被宿主吸收，因为它们履行重要的生物学功能，包括胎盘发育和保护免受相关外源性逆转录病毒的侵害。特别是，两个enJSRV基因座，enJS 56 A1和enJSRV-20，积极选择在绵羊驯化，由于他们的能力，干扰相关的主管逆转录病毒的复制。有趣的是，逃避这些转显性enJSRVs的病毒最近出现了，可能不到200年前。总的来说，这些研究结果表明，在绵羊中的内源化过程仍在进行中，因此，内源性和外源性绵羊β逆转录病毒及其宿主之间的进化相互作用尚未达到平衡。
Sheep betaretroviruses represent a fascinating model to study the complex evolutionary interplay between host and pathogen in natural settings. In infected sheep, the exogenous and pathogenic Jaagsiekte sheep retrovirus (JSRV) coexists with a variety of highly related endogenous JSRVs, referred to as enJSRVs. During evolution, some of them were co-opted by the host as they fulfilled important biological functions, including placental development and protection against related exogenous retroviruses. In particular, two enJSRV loci, enJS56A1 and enJSRV-20, were positively selected during sheep domestication due to their ability to interfere with the replication of related competent retroviruses. Interestingly, viruses escaping these transdominant enJSRVs have recently emerged, probably less than 200 years ago. Overall, these findings suggest that in sheep the process of endogenization is still ongoing and, therefore, the evolutionary interplay between endogenous and exogenous sheep betaretroviruses and their host has not yet reached an equilibrium.
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DOI：
10.1111/j.1600-0897.2010.00860.x
发表时间：
2010-10
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Black SG;Arnaud F;Palmarini M;Spencer TE
通讯作者：
Spencer TE
影响因子：
3.8
作者：
Dunlap, K. A.;Palmarini, M.;Spencer, T. E.
通讯作者：
Spencer, T. E.
影响因子：
5.4
作者：
Alberti, A;Murgia, C;Palmarini, M
通讯作者：
Palmarini, M
影响因子：
3.7
作者：
Caporale, M;Centorame, P;Palmarini, M
通讯作者：
Palmarini, M
影响因子：
3.7
作者：
Cousens, Chris;Maeda, Naoyoshi;Fan, Hung
通讯作者：
Fan, Hung