Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria.
Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria.
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DOI：
10.1186/s12866-021-02292-1
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发表时间：
2021-08-24
期刊：
影响因子：
4.2
通讯作者：
Watanabe K
中科院分区：
文献类型：
--
作者：
Tsunematsu Y;Hosomi K;Kunisawa J;Sato M;Shibuya N;Saito E;Murakami H;Yoshikawa Y;Iwashita Y;Miyoshi N;Mutoh M;Ishikawa H;Sugimura H;Miyachi M;Wakabayashi K;Watanabe K
已知大肠杆菌菌株可产生遗传毒性次级代谢产物大肠杆菌素，与结直肠肿瘤发生有关。因此，了解这种大肠杆菌素阳性的E。大肠杆菌素致癌的分子机制的研究为大肠癌的早期诊断和预防提供了可能。虽然在大肠杆菌素阳性E.大肠杆菌及其产生的毒素，clb +菌株的感染途径仍然很难确定。我们检查了婴儿和他们在出生期间和出生后的治疗，以检查大肠杆菌阳性E。大肠杆菌感染婴儿。在这里，对出生第一个月的婴儿粪便样本进行的大肠杆菌素生物合成基因的分析显示，这种细菌可能通过亲密接触（如自然分娩和母乳喂养）从母亲传播给婴儿，但不是通过食物摄入。我们的发现提示大肠杆菌素阳性的E。大肠杆菌的感染似乎在新生儿生命的早期阶段发生，这暗示了制定早期预防措施以预防结肠直肠癌的可能性。在线版本包含补充材料，可通过10.1186/s12866-021-02292-1获得。
The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular mechanism of oncogenesis by colibactin may provide us with opportunities for early diagnosis or prevention of colorectal oncogenesis. While there have been major advances in the characterization of colibactin-positive E. coli and the toxin it produces, the infection route of the clb + strain remains poorly characterized. We examined infants and their treatments during and post-birth periods to examine potential transmission of colibactin-positive E. coli to infants. Here, analysis of fecal samples of infants over the first month of birth for the presence of a colibactin biosynthetic gene revealed that the bacterium may be transmitted from mother to infant through intimate contacts, such as natural childbirth and breastfeeding, but not through food intake. Our finding suggests that transmission of colibactin-positive E. coli appears to be occurring at the very early stage of life of the newborn and hints at the possibility of developing early preventive measures against colorectal cancer. The online version contains supplementary material available at 10.1186/s12866-021-02292-1.
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影响因子：
7.3
作者：
Arrieta MC;Stiemsma LT;Amenyogbe N;Brown EM;Finlay B
通讯作者：
Finlay B
影响因子：
3.2
作者：
Bian, Xiaoying;Fu, Jun;Mueller, Rolf
通讯作者：
Mueller, Rolf
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C
影响因子：
1.7
作者：
Huang B;Fettweis JM;Brooks JP;Jefferson KK;Buck GA
通讯作者：
Buck GA
影响因子：
30.3
作者：
Yassour M;Jason E;Hogstrom LJ;Arthur TD;Tripathi S;Siljander H;Selvenius J;Oikarinen S;Hyöty H;Virtanen SM;Ilonen J;Ferretti P;Pasolli E;Tett A;Asnicar F;Segata N;Vlamakis H;Lander ES;Huttenhower C;Knip M;Xavier RJ
通讯作者：
Xavier RJ