Physical Exercise Improves Cognitive Function Together with Microglia Phenotype Modulation and Remyelination in Chronic Cerebral Hypoperfusion.
Physical Exercise Improves Cognitive Function Together with Microglia Phenotype Modulation and Remyelination in Chronic Cerebral Hypoperfusion.
复制标题
体育锻炼可改善慢性脑灌注不足的认知功能以及小胶质细胞表型调节和髓鞘再生
DOI：
10.3389/fncel.2017.00404
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发表时间：
2017
影响因子：
5.3
通讯作者：
Hu X
中科院分区：
文献类型：
--
作者：
Jiang T;Zhang L;Pan X;Zheng H;Chen X;Li L;Luo J;Hu X
髓鞘与认知功能密切相关，在缺血性脑血管病中极易受损。髓鞘再生的失败主要是由于受损区域中少突胶质祖细胞（OPCs）分化的限制。既往研究表明，体育锻炼可以改善血管性认知功能障碍，但能否逆转缺血性损伤时髓鞘再生的缺陷及其机制尚不清楚。本研究观察了运动对双侧颈总动脉闭塞所致慢性脑低灌注（CCH）的影响。术后28 d观察大鼠认知功能、髓鞘完整性、OPCs增殖分化及小胶质细胞极化情况。此外，还检测了CX 3CL 1/CX 3CR 1轴的表达和丝裂原活化蛋白激酶（MAPK）信号级联的激活。结果发现，运动可改善CCH大鼠的认知功能，减轻髓鞘损伤，促进OPCs增殖和分化，促进小胶质细胞向M2方向极化，增加CX 3CL 1/CX 3CR 1轴的表达，降低ERK和JNK磷酸化水平。结果表明，体育锻炼可以改善慢性脑血管病大鼠的认知功能，这可能是通过调节小胶质细胞表型以及增强少突胶质细胞的发生和髓鞘再生来实现的。此外，CX 3CL 1/CX 3CR 1轴通过介导ERK和JNK依赖性途径在此过程中发挥重要作用。
Myelin is closely associated with cognitive function and is extremely vulnerable to damage in ischemic cerebrovascular diseases. The failure of remyelination is mainly due to limitations in oligodendrocyte progenitor cells (OPCs) differentiation in the damaged area. Previous studies have shown that physical exercise can improve vascular cognitive impairment, but whether it can reverse the defect in remyelination during ischemic injury and the underlying mechanism remains unclear. In this study, we observed the effects of physical exercise on chronic cerebral hypoperfusion (CCH) established by bilateral carotid artery occlusion. The cognitive function, myelin integrity, OPCs proliferation and differentiation, as well as microglia polarization were analyzed at 28 days after CCH. Besides, the expression of CX3CL1/CX3CR1 axis and activation of mitogen-activated protein kinase (MAPK) signal cascades were also evaluated. We found that physical exercise improved the cognitive function of rats with CCH, alleviated myelin injury, triggered OPCs proliferation and differentiation, facilitated microglia polarization toward M2, augmented the expression of CX3CL1/CX3CR1 axis, and reduced ERK and JNK phosphorylation. The results indicated that physical exercise improved the cognitive function of rats with CCH, possibly through microglial phenotype modulation and enhancement of oligodendrocytegenesis and remyelination. Moreover, the CX3CL1/CX3CR1 axis played an important role in this process by mediating ERK- and JNK-dependent pathways.
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影响因子：
15.1
作者：
Kohman, Rachel A.;DeYoung, Erin K.;Bhattacharya, Tushar K.;Peterson, Lindsey N.;Rhodes, Justin S.
通讯作者：
Rhodes, Justin S.
影响因子：
4.2
作者：
Bachstetter, Adam D.;Morganti, Josh M.;Jernberg, Jennifer;Schlunk, Andrea;Mitchell, Staten H.;Brewster, Kaelin W.;Hudson, Charles E.;Cole, Michael J.;Harrison, Jeffrey K.;Bickford, Paula C.;Gemma, Carmelina
通讯作者：
Gemma, Carmelina
影响因子：
15.9
作者：
Kreutzberg, GW
通讯作者：
Kreutzberg, GW
DOI：
10.1073/pnas.95.18.10896
发表时间：
1998-09-01
影响因子：
11.1
作者：
Harrison, JK;Jiang, Y;Feng, LL
通讯作者：
Feng, LL
影响因子：
6.2
作者：
Back, Stephen A.;Rosenberg, Paul A.
通讯作者：
Rosenberg, Paul A.