A review of combined experimental and computational procedures for assessing biopolymer structure-process-property relationships.
A review of combined experimental and computational procedures for assessing biopolymer structure-process-property relationships.
复制标题
对评估生物聚合物结构过程 - 过程关系的合并实验和计算程序的综述。
DOI：
10.1016/j.biomaterials.2012.06.054
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发表时间：
2012-11
期刊：
影响因子：
14
通讯作者：
Buehler, Markus J.
中科院分区：
文献类型：
--
作者：
Gronau, Greta;Krishnaji, Sreevidhya T.;Kinahan, Michelle E.;Giesa, Tristan;Wong, Joyce Y.;Kaplan, David L.;Buehler, Markus J.
具有可调功能特性的定制生物材料在从药物输送到再生医学的许多应用中都是可取的。为了提高生物聚合物材料功能的可预测性，需要考虑多个设计参数以及适当的模型。在这篇文章中，我们回顾了与生物聚合物设计相关的合成和加工的技术现状，重点是自下而上的计算模型在设计过程中的集成。我们考虑了三个研究得很好的生物聚合物材料的突出例子-弹性蛋白、丝素和胶原-并评估了它们的层次结构、有趣的功能特性，并对现有的研究这些材料的方法进行了分类。我们发现，由于难以将在不同长度和时间尺度上获得的见解联系起来，因此很少将实验和计算建模结合在一起的综合设计方法应用于这些材料。在这种背景下，多尺度工程提供了一种强有力的手段来加速生物材料的设计过程，以开发适合各种应用所提出的需求的定制材料。实验和计算工具的结合使用不仅在生物聚合物领域具有非常广泛的适用性，而且可以被用来定制其他聚合物和复合材料的一般性能。
Tailored biomaterials with tunable functional properties are desirable for many applications ranging from drug delivery to regenerative medicine. To improve the predictability of biopolymer materials functionality, multiple design parameters need to be considered, along with appropriate models. In this article we review the state of the art of synthesis and processing related to the design of biopolymers, with an emphasis on the integration of bottom-up computational modeling in the design process. We consider three prominent examples of well-studied biopolymer materials – elastin, silk, and collagen – and assess their hierarchical structure, intriguing functional properties and categorize existing approaches to study these materials. We find that an integrated design approach in which both experiments and computational modeling are used has rarely been applied for these materials due to difficulties in relating insights gained on different length- and time-scales. In this context, multiscale engineering offers a powerful means to accelerate the biomaterials design process for the development of tailored materials that suit the needs posed by the various applications. The combined use of experimental and computational tools has a very broad applicability not only in the field of biopolymers, but can be exploited to tailor the properties of other polymers and composite materials in general.
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影响因子：
3.1
作者：
Boland, ED;Matthews, JA;Bowlin, GL
通讯作者：
Bowlin, GL
影响因子：
3.7
作者：
Chen, Tze-Haw Howard;Bae, Younsoo;Furgeson, Darin Y.
通讯作者：
Furgeson, Darin Y.
影响因子：
2.9
作者：
Bratzel, Graham;Buehler, Markus J.
通讯作者：
Buehler, Markus J.
影响因子：
2.9
作者：
CAPPELLO, J;CRISSMAN, J;FERRARI, F
通讯作者：
FERRARI, F
影响因子：
14
作者：
Altman, GH;Diaz, F;Kaplan, DL
通讯作者：
Kaplan, DL