Comparative Vascular Pharmacology of the Atriopeptins
Comparative Vascular Pharmacology of the Atriopeptins
复制标题
心房肽的比较血管药理学
作者：
K. Wakitani;T. Oshima;A. Loewy;S. Holmberg;B. Cole;S. Adams;K. Fok;M. Currie;P. Needleman
心房肽是去甲肾上腺素收缩的主动脉条的有效松弛剂，或者是去甲肾上腺素收缩的离体灌注大鼠肾脏中肾血管的扩张剂。心房肽的这种血管舒张性质需要苯丙氨酸精氨酸的存在（即，心房肽II、III或ser-leu-arg-arg心房肽III）残基，其比心房肽I（缺少phe-arg C-末端的21个氨基酸肽）或核心肽（残基3-19）有效得多。然而，这些人工体外预收缩制剂不能准确预测心房肽在完整大鼠中的血管有效性。对麻醉大鼠静脉给予心房肽（包括心房肽I）可产生浓度依赖性低血压、低剂量肾阻力选择性降低（用微球测定）和明显利尿。在更高的剂量下，心房肽增加其他血管床的血流量。另一方面，在麻醉的狗中，注射（动脉内）含phe-arg的肽产生肾血流量和钠排泄的浓度依赖性增加，而心房肽素I是无活性的。尽管对心房肽I的反应性存在种属差异，但这些数据表明，这种新型心房肽家族产生的肾血管舒张和利尿之间存在直接相关性。
The atriopeptins are potent relaxants of norepinephrine-constricted aortic strips or are dilators of renal blood vessels in isolated perfused rat kidneys that are constricted by norepinephrine. This vasorelaxant property of the atriopeptins requires the presence of phenylalanine arginine (i.e., atriopeptin II, III, or ser-leu-arg-arg atriopeptin III) residues in the carboxy terminus which are considerably more effective than atriopeptin I (the 21 amino acid peptide which lacks the phe-arg C-terminus) or the core peptide (residues 3–19). However, these artificially in vitro precontracted preparations do not accurately predict the vascular effectiveness of the atriopeptins in intact rats. Intravenous administration of the atriopeptins (including atriopeptin I) to anesthetized rats produces concentration-dependent hypotension, a selective decrease in renal resistance in low doses (determined with microspheres), and pronounced diuresis. At higher doses, atriopeptins increase blood flow in other vascular beds. On the other hand, in the anesthetized dog, injection (intraarterially) of the phe-arg-containing peptides produces a concentration- dependent increase in both renal blood flow and sodium excretion, whereas atriopeptin I is inactive. Although there is a species difference in responsiveness to atriopeptin I, these data demonstrate a direct correlation between the renal vasodilation and diuresis produced by this novel family of atrial peptides.
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DOI：
10.1016/s0006-291x(84)80279-x
发表时间：
1984-03
影响因子：
3.1
作者：
K. Misono;H. Fukumi;R. Grammer;T. Inagami
通讯作者：
K. Misono;H. Fukumi;R. Grammer;T. Inagami
影响因子：
56.9
作者：
C. Seidman;A. Duby;E. Choi;R. Graham;E. Haber;C. Homcy;J. Smith;J. Seidman
通讯作者：
C. Seidman;A. Duby;E. Choi;R. Graham;E. Haber;C. Homcy;J. Smith;J. Seidman
从 cDNA 序列推导的大鼠心房钠尿因子前体的结构。
影响因子：
64.8
作者：
Maki,M;Takayanagi,R;Misono,KS;Pandey,KN;Tibbetts,C;Inagami,T
通讯作者：
Inagami,T
大鼠的血流动力学紊乱与注射的微球数量有关。
DOI：
10.1152/ajpheart.1983.245.6.h920
发表时间：
1983
期刊：
The American journal of physiology
影响因子：
--
作者：
Stanek,KA;Smith,TL;Murphy,WR;Coleman,TG
通讯作者：
Coleman,TG
L-谷氨酸刺激A5细胞组后局部血流量和心输出量的变化。
DOI：
10.1152/ajpheart.1984.246.1.h44
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Stanek,KA;Neil,JJ;Sawyer,WB;Loewy,AD
通讯作者：
Loewy,AD