A visual encoding model links magnetoencephalography signals to neural synchrony in human cortex.

A visual encoding model links magnetoencephalography signals to neural synchrony in human cortex.
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视觉编码模型将脑磁图信号与人类皮层的神经同步联系起来。

DOI:
10.1016/j.neuroimage.2021.118655
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发表时间:
2021-12-15
期刊:
影响因子:
5.7
通讯作者:
Winawer J
Winawer J
中科院分区:
医学1区
文献类型:
--
作者:
Kupers ER;Benson NC;Winawer J

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假设远距离神经元反应的同步对许多皮质功能都很重要。然而,目前还没有直接的方法来评估人脑的非侵入性同步。MEG和EEG测量的是整个大脑,但传感器集中在大面积重叠的皮质区域,掩盖了潜在的神经同步性。在这里,我们建立了一个从刺激到皮层到MEG传感器的模型,以解开仪器空间池中的神经同步。我们发现跨皮层的同步对预测的脑磁脑图空间地形有着惊人的大而系统的影响。然后,我们进行了视觉脑磁图实验,并将反应分为刺激锁定和宽带部分。刺激锁定地形与假设同步神经源的模型预测相似,而宽带地形与假设异步神经源的模型预测相似。我们推断,视觉刺激引发了两种不同类型的神经反应,一种是高度同步的,另一种是基本不同步的。
Synchronization of neuronal responses over large distances is hypothesized to be important for many cortical functions. However, no straightforward methods exist to estimate synchrony non-invasively in the living human brain. MEG and EEG measure the whole brain, but the sensors pool over large, overlapping cortical regions, obscuring the underlying neural synchrony. Here, we developed a model from stimulus to cortex to MEG sensors to disentangle neural synchrony from spatial pooling of the instrument. We find that synchrony across cortex has a surprisingly large and systematic effect on predicted MEG spatial topography. We then conducted visual MEG experiments and separated responses into stimulus-locked and broadband components. The stimulus-locked topography was similar to model predictions assuming synchronous neural sources, whereas the broadband topography was similar to model predictions assuming asynchronous sources. We infer that visual stimulation elicits two distinct types of neural responses, one highly synchronous and one largely asynchronous across cortex.
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