Whole-Cerebrum distortion-free three-dimensional pseudo-continuous arterial spin labeling at 7T.
Whole-Cerebrum distortion-free three-dimensional pseudo-continuous arterial spin labeling at 7T.
复制标题
全甲状腺无失真的三维伪连续性动脉自旋标记在7T处。
DOI：
10.1016/j.neuroimage.2023.120251
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发表时间：
2023-08-15
期刊：
影响因子：
5.7
通讯作者：
Wang, Danny J. J.
中科院分区：
文献类型：
--
作者：
Zhao, Chenyang;Shao, Xingfeng;Shou, Qinyang;Ma, Samantha J.;Gokyar, Sayim;Graf, Christina;Stollberger, Rudolf;Wang, Danny J. J.
关键词：
B1/B 0不均匀性影响pCASL标记、背景抑制（BS）和读出序列，从而阻碍了伪连续动脉自旋标记（pCASL）的磁共振场的实现潜力。本研究旨在通过优化pCASL标记参数、BS脉冲和加速Turbo-FLASH（TFL）读出，在7 T下呈现全脑无畸变的三维（3D）pCASL序列。提出了一组新的pCASL标记参数（Gave = 0.4 mT/m，Gratio = 14.67），以避免底部切片中的干扰，同时实现稳健的标记效率（LE）。基于7 T下B1/B 0非均匀性范围设计了OPTIM BS脉冲。开发了具有2D-CAIPIRINHA欠采样和中心排序的3D TFL读出，并且在模拟中改变段数（Nseg）和翻转角（FA）以实现SNR和空间模糊之间的最佳折衷。对19名受试者进行了体内实验。结果表明，新的一组标记参数有效地实现了整个大脑的覆盖，消除干扰的底部切片，同时保持高LE。与原始BS脉冲相比，OPTIM BS脉冲在灰质（GM）中实现了高33.3%的灌注信号，成本为SAR的4.8倍。在中等FA（8°）和Nseg（2）的情况下，与3D GRASE-pCASL相比，全脑3D TFL-pCASL成像的分辨率为2 × 2 × 4 mm 3，无失真和敏感性伪影。此外，3D TFL-pCASL显示出良好至优异的重测重复性和更高分辨率（2 mm各向同性）的潜力。与3 T下的相同序列和7 T下的同时多切片TFL-pCASL相比，所提出的技术还显著提高了SNR。通过结合一组新的标记参数、OPTIM BS脉冲和加速的3D TFL读出，我们在7 T下实现了高分辨率pCASL，具有全脑覆盖、详细的灌注和解剖信息而没有失真以及足够的SNR。
Fulfilling potentials of ultrahigh field for pseudo-Continuous Arterial Spin Labeling (pCASL) has been hampered by B1/B0 inhomogeneities that affect pCASL labeling, background suppression (BS), and the readout sequence. This study aimed to present a whole-cerebrum distortion-free three-dimensional (3D) pCASL sequence at 7T by optimizing pCASL labeling parameters, BS pulses, and an accelerated Turbo-FLASH (TFL) readout. A new set of pCASL labeling parameters (Gave = 0.4 mT/m, Gratio = 14.67) was proposed to avoid interferences in bottom slices while achieving robust labeling efficiency (LE). An OPTIM BS pulse was designed based on the range of B1/B0 inhomogeneities at 7T. A 3D TFL readout with 2D-CAIPIRINHA undersampling and centric ordering was developed, and the number of segments (Nseg) and flip angle (FA) were varied in simulation to achieve the optimal trade-off between SNR and spatial blurring. In-vivo experiments were performed on 19 subjects. The results showed that the new set of labeling parameters effectively achieved whole-cerebrum coverage by eliminating interferences in bottom slices while maintaining a high LE. The OPTIM BS pulse achieved 33.3% higher perfusion signal in gray matter (GM) than the original BS pulse with a cost of 4.8-fold SAR. Incorporating a moderate FA (8°) and Nseg (2), whole-cerebrum 3D TFL-pCASL imaging was achieved with a 2 × 2 × 4 mm3 resolution without distortion and susceptibility artifacts compared to 3D GRASE-pCASL. In addition, 3D TFL-pCASL showed a good to excellent test-retest repeatability and potential of higher resolution (2 mm isotropic). The proposed technique also significantly improved SNR when compared to the same sequence at 3T and simultaneous multislice TFL-pCASL at 7T. By combining a new set of labeling parameters, OPTIM BS pulse, and accelerated 3D TFL readout, we achieved high resolution pCASL at 7T with whole-cerebrum coverage, detailed perfusion and anatomical information without distortion, and sufficient SNR.
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