Motor cortex is required for learning but not for executing a motor skill.
Motor cortex is required for learning but not for executing a motor skill.
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DOI：
10.1016/j.neuron.2015.03.024
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发表时间：
2015-05-06
期刊：
影响因子：
16.2
通讯作者：
Ölveczky BP
中科院分区：
文献类型：
--
作者：
Kawai R;Markman T;Poddar R;Ko R;Fantana AL;Dhawale AK;Kampff AR;Ölveczky BP
人们普遍认为运动皮层是运动技能获取和执行的基础，但它对这些过程的贡献尚未完全了解。原因之一是，对运动技能的研究经常将运动皮层在灵巧控制中的既定作用与学习和产生特定任务运动序列中的作用混为一谈。为了分离这些方面，我们为老鼠开发了一项运动任务，可以训练时空精确的运动模式，而不需要灵活性。值得注意的是，运动皮层损伤对获得的技能没有明显的影响，这些技能在损伤后训练的第一天以其独特的损伤前形式表达。然而，训练前运动皮层的损伤使得大鼠无法获得任务所需的刻板运动序列。这些结果表明，皮层下运动回路具有执行所学技能的非凡能力，以及运动皮层在学习过程中“辅导”这些回路方面的先前未被认识到的作用。
Motor cortex is widely believed to underlie the acquisition and execution of motor skills, yet its contributions to these processes are not fully understood. One reason is that studies on motor skills often conflate motor cortex’s established role in dexterous control with roles in learning and producing task-specific motor sequences. To dissociate these aspects, we developed a motor task for rats that trains spatiotemporally precise movement patterns without requirements for dexterity. Remarkably, motor cortex lesions had no discernible effect on the acquired skills, which were expressed in their distinct pre-lesion forms on the very first day of post-lesion training. Motor cortex lesions prior to training, however, rendered rats unable to acquire the stereotyped motor sequences required for the task. These results suggest a remarkable capacity of subcortical motor circuits to execute learned skills and a previously unappreciated role for motor cortex in ‘tutoring’ these circuits during learning.
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影响因子：
16.2
作者：
Ali F;Otchy TM;Pehlevan C;Fantana AL;Burak Y;Ölveczky BP
通讯作者：
Ölveczky BP
影响因子：
5.3
作者：
Bonazzi, Laura;Viaro, Riccardo;Franchi, Gianfranco
通讯作者：
Franchi, Gianfranco
影响因子：
1.8
作者：
Darling WG;Pizzimenti MA;Morecraft RJ
通讯作者：
Morecraft RJ
DOI：
10.1073/pnas.0903214106
发表时间：
2009-07-28
影响因子：
11.1
作者：
Andalman, Aaron S.;Fee, Michale S.
通讯作者：
Fee, Michale S.
影响因子：
2.9
作者：
Golowasch, J;Casey, M;Marder, E
通讯作者：
Marder, E