The connectome of the Caenorhabditis elegans pharynx.
The connectome of the Caenorhabditis elegans pharynx.
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DOI：
10.1002/cne.24932
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发表时间：
2020-11-01
期刊：
影响因子：
--
通讯作者：
Hobert O
中科院分区：
文献类型：
--
作者：
Cook SJ;Crouse CM;Yemini E;Hall DH;Emmons SW;Hobert O
单个器官和整个动物的详细解剖图是随后解剖其进化、发育和功能的宝贵切入点。线虫的咽是一个简单的神经肌肉器官，具有独立自主的神经系统，由20个神经元组成，分为14种解剖学上不同的类型。使用连续EM重建，我们在这里重新评估了咽神经系统的连接体，为其结构和预测功能提供了新颖且更详细的视图。对比以前的分类咽神经元到不同的间和运动神经元类，我们提供的证据表明，大多数咽神经元也可能是感觉神经元和大多数，如果不是全部，咽神经元也归类为运动神经元。与广泛的交叉连接之间的咽神经元，这是更广泛的比以前实现的，大多数神经元的感觉运动特性定义了一个浅的网络结构的咽连接。网络分析表明，神经元连接的模式被组织成假定的计算模块，反映了已知的功能域的咽。与躯体神经系统相比，咽神经元在物理上与更大比例的相邻神经元相关联，并与更大比例的相邻神经元形成突触。我们推测咽神经系统的整体结构可能会让人想起祖先的原始神经系统的结构。
Detailed anatomical maps of individual organs and entire animals have served as invaluable entry points for ensuing dissection of their evolution, development, and function. The pharynx of the nematode Caenorhabditis elegans is a simple neuromuscular organ with a self-contained, autonomously acting nervous system, composed of 20 neurons that fall into 14 anatomically distinct types. Using serial EM reconstruction, we re-evaluate here the connectome of the pharyngeal nervous system, providing a novel and more detailed view of its structure and predicted function. Contrasting the previous classification of pharyngeal neurons into distinct inter- and motor neuron classes, we provide evidence that most pharyngeal neurons are also likely sensory neurons and most, if not all, pharyngeal neurons also classify as motor neurons. Together with the extensive cross-connectivity among pharyngeal neurons, which is more widespread than previously realized, the sensory-motor characteristics of most neurons define a shallow network architecture of the pharyngeal connectome. Network analysis reveals that the patterns of neuronal connections are organized into putative computational modules that reflect the known functional domains of the pharynx. Compared to the somatic nervous system, pharyngeal neurons both physically associate with a larger fraction of their neighbors and create synapses with a greater proportion of their neighbors. We speculate that the overall architecture of the pharyngeal nervous system may be reminiscent of the architecture of ancestral, primitive nervous systems.
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影响因子：
7.7
作者：
Gendrel, Marie;Atlas, Emily G.;Hobert, Oliver
通讯作者：
Hobert, Oliver
影响因子：
16.2
作者：
Bhatla, Nikhil;Horvitz, H. Robert
通讯作者：
Horvitz, H. Robert
影响因子：
--
作者：
AVERY, L;HORVITZ, HR
通讯作者：
HORVITZ, HR
影响因子：
2.7
作者：
CASSADA, RC;RUSSELL, RL
通讯作者：
RUSSELL, RL
DOI：
10.1088/1742-5468/2008/10/p10008
发表时间：
2008-10-01
影响因子：
2.4
作者：
Blondel, Vincent D.;Guillaume, Jean-Loup;Lefebvre, Etienne
通讯作者：
Lefebvre, Etienne