Effect of diabetes mellitus type 2 on salivary glucose--a systematic review and meta-analysis of observational studies.
Effect of diabetes mellitus type 2 on salivary glucose--a systematic review and meta-analysis of observational studies.
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DOI：
10.1371/journal.pone.0101706
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Barahona I
中科院分区：
文献类型：
--
作者：
Mascarenhas P;Fatela B;Barahona I
2型糖尿病（DM）的早期筛查对于改善预后以及有效延缓临床并发症至关重要。然而，高血糖检测往往需要有创且疼痛的血液检测，这限制了其大规模应用。我们将新的未发表数据与已发表的数据相结合，这些数据比较了2型糖尿病患者和对照组的唾液葡萄糖水平，并且/或者研究了唾液葡萄糖与血糖/糖化血红蛋白（HbA1c）之间的相关性，以系统地评估唾液葡萄糖用于估算血糖和HbA1c的有效性。我们进一步探讨了唾液葡萄糖作为大规模筛查糖尿病或2型糖尿病发病的生物标志物的可能性。
我们对经过同行评审的已发表文章进行了荟萃分析，这些文章报告了2型糖尿病患者和非糖尿病个体的平均唾液葡萄糖水平以及/或者唾液葡萄糖水平与血糖或HbA1c之间相关性的数据，并将它们与我们自己未发表的结果相结合。我们对唾液葡萄糖水平的标准化均数差进行的整体荟萃分析显示，2型糖尿病对唾液葡萄糖有总体较大的正向影响（Hedge's g = 1.37）。唾液葡萄糖与血糖之间的整体相关系数（r）较大（r = 0.49），亚组的相关系数从中等（非糖尿病患者中r = 0.30）到非常大（糖尿病患者中r = 0.67）不等。对唾液葡萄糖与HbA1c之间整体相关性的荟萃分析显示，总体关联强度为中等（r = 0.37）。
我们的系统综述报告了2型糖尿病患者唾液葡萄糖浓度总体上有显著升高，并且唾液葡萄糖浓度与相关的血糖/HbA1c值之间存在显著的总体关系，且血糖/HbA1c值越高，相关性越强。这些结果支持了唾液葡萄糖水平作为2型糖尿病生物标志物的潜力，为2型糖尿病的筛查以及监测大量糖尿病患者的血糖水平提供了一种痛苦更小/侵入性更低的方法。
Early screening of type 2 diabetes mellitus (DM) is essential for improved prognosis and effective delay of clinical complications. However, testing for high glycemia often requires invasive and painful blood testing, limiting its large-scale applicability. We have combined new, unpublished data with published data comparing salivary glucose levels in type 2 DM patients and controls and/or looked at the correlation between salivary glucose and glycemia/HbA1c to systematically review the effectiveness of salivary glucose to estimate glycemia and HbA1c. We further discuss salivary glucose as a biomarker for large-scale screening of diabetes or developing type 2 DM. We conducted a meta-analysis of peer-reviewed published articles that reported data regarding mean salivary glucose levels and/or correlation between salivary glucose levels and glycemia or HbA1c for type 2 DM and non-diabetic individuals and combined them with our own unpublished results. Our global meta-analysis of standardized mean differences on salivary glucose levels shows an overall large positive effect of type 2 DM over salivary glucose (Hedge's g = 1.37). The global correlation coefficient (r) between salivary glucose and glycemia was large (r = 0.49), with subgroups ranging from medium (r = 0.30 in non-diabetics) to very large (r = 0.67 in diabetics). Meta-analysis of the global correlation between salivary glucose and HbA1c showed an overall association of medium strength (r = 0.37). Our systematic review reports an overall meaningful salivary glucose concentration increase in type 2 DM and a significant overall relationship between salivary glucose concentration and associated glycemia/HbA1c values, with the strength of the correlation increasing for higher glycemia/HbA1c values. These results support the potential of salivary glucose levels as a biomarker for type 2 DM, providing a less painful/invasive method for screening type 2 DM, as well as for monitoring blood glucose levels in large cohorts of DM patients.
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影响因子：
4.2
作者：
Hofman, LF
通讯作者：
Hofman, LF
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG
影响因子：
--
作者：
Jurysta C;Bulur N;Oguzhan B;Satman I;Yilmaz TM;Malaisse WJ;Sener A
通讯作者：
Sener A
DOI：
10.2147/dmso.s32112
发表时间：
2012
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
Abikshyeet P;Ramesh V;Oza N
通讯作者：
Oza N
影响因子：
39.2
作者：
Calonge, Ned;Petitti, Diana B.;Yawn, Barbara P.
通讯作者：
Yawn, Barbara P.