The Potential Role of Curcumin in Modulating the Master Antioxidant Pathway in Diabetic Hypoxia-Induced Complications.
The Potential Role of Curcumin in Modulating the Master Antioxidant Pathway in Diabetic Hypoxia-Induced Complications.
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姜黄素在调节糖尿病缺氧引起的并发症中的主抗氧化剂途径中的潜在作用。
DOI：
10.3390/molecules26247658
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发表时间：
2021-12-17
期刊：
影响因子：
--
通讯作者：
Moosavi-Movahedi AA
中科院分区：
文献类型：
--
作者：
Ghareghomi S;Rahban M;Moosavi-Movahedi Z;Habibi-Rezaei M;Saso L;Moosavi-Movahedi AA
氧化应激是多种疾病发生和发展的主要因素。Keap 1-Nrf 2通路是一个关键的抗氧化系统，可以保持细胞的氧化还原平衡。它减少炎症，其中Nrf 2作为转录因子的核转位促进细胞中的各种抗氧化反应。通过一些其他的方向和调节蛋白，该途径在预防多种疾病和减少其并发症方面发挥着基础性作用。Nrf 2通路的调节发生在转录和转录后水平，并且这些调节在其活性中起重要作用。Nrf 2通路与PI 3激酶/AKT/mTOR、NF-κB和HIF-1因子等关键信号通路之间存在微妙的相关性。这表明了它在各种疾病的发展中的作用。姜黄素（Curcumin）是从姜黄（Curcumalonga）中提取的一种黄色多酚类化合物，具有抗氧化、抗炎、抗肿瘤、抗病毒等多种生物活性。由于高血糖和活性氧（ROS）增加是常见糖尿病并发症的主要原因，减少ROS的产生可能是处理这些并发症的根本方法。姜黄素可以被认为是一种潜在的治疗选择，它可以创造一种有效的治疗方法来抵消ROS并减少其有害影响。本文综述了Nrf 2通路在不同水平上的调节及其与细胞中参与糖尿病并发症进展的其他重要通路和蛋白的相关性，并通过姜黄素靶向这些通路进行了研究。
Oxidative stress is the leading player in the onset and development of various diseases. The Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells’ redox balance. It decreases inflammation in which the nuclear trans-localization of Nrf2 as a transcription factor promotes various antioxidant responses in cells. Through some other directions and regulatory proteins, this pathway plays a fundamental role in preventing several diseases and reducing their complications. Regulation of the Nrf2 pathway occurs on transcriptional and post-transcriptional levels, and these regulations play a significant role in its activity. There is a subtle correlation between the Nrf2 pathway and the pivotal signaling pathways, including PI3 kinase/AKT/mTOR, NF-κB and HIF-1 factors. This demonstrates its role in the development of various diseases. Curcumin is a yellow polyphenolic compound from Curcuma longa with multiple bioactivities, including antioxidant, anti-inflammatory, anti-tumor, and anti-viral activities. Since hyperglycemia and increased reactive oxygen species (ROS) are the leading causes of common diabetic complications, reducing the generation of ROS can be a fundamental approach to dealing with these complications. Curcumin can be considered a potential treatment option by creating an efficient therapeutic to counteract ROS and reduce its detrimental effects. This review discusses Nrf2 pathway regulation at different levels and its correlation with other important pathways and proteins in the cell involved in the progression of diabetic complications and targeting these pathways by curcumin.
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影响因子：
13.8
作者：
Abraham NG;Junge JM;Drummond GS
通讯作者：
Drummond GS
影响因子：
10.5
作者：
Brancho, D;Tanaka, N;Davis, RJ
通讯作者：
Davis, RJ
NRF2：Beta细胞命运的主人和队长。
DOI：
10.1016/j.tem.2020.11.002
发表时间：
2021-01
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Baumel-Alterzon S;Katz LS;Brill G;Garcia-Ocaña A;Scott DK
通讯作者：
Scott DK
影响因子：
5.6
作者：
Bucolo, Claudio;Drago, Filippo;Giunta, Salvatore
通讯作者：
Giunta, Salvatore
影响因子：
4.1
作者：
Balogun, E;Hoque, M;Motterlini, R
通讯作者：
Motterlini, R