Murine leukemia viruses with recombinant env genes: a discussion of their role in leukemogenesis.
Murine leukemia viruses with recombinant env genes: a discussion of their role in leukemogenesis.
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具有重组 env 基因的鼠白血病病毒：对其在白血病发生中的作用的讨论。
DOI：
10.1007/978-3-642-68943-7_4
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发表时间：
1983
影响因子：
--
通讯作者：
Famulari,NG
中科院分区：
文献类型：
--
作者：
Famulari,NG
1951 年，Ludwik Gross 报道了证明某些小鼠白血病的病毒病因的实验。他的工作确定了 AKR 胸腺瘤无细胞提取物中存在感染因子，这种感染因子可以将白血病传播给 C3Hf/Bi 小鼠 (Gross1951)。随后的电子显微镜分析表明，在按照 Gross 方案（DmochowskiandGrey1957；Bernhard1960）在 C3Hf/Bi 小鼠中诱导的 AKR 胸腺瘤和白血病制剂中，存在具有鼠白血病病毒特征性 c 型形态的病毒颗粒。在接下来的 30 年里，人们已经清楚地认识到，鼠白血病病毒 (MuLV) 是一个多态性感染因子家族，它们在小鼠中诱发疾病的能力，甚至在小鼠细胞中感染和复制的能力都具有异质性（综述参见Stephenson1980）。 MuLV 的宿主范围类别已被定义为亲嗜性（即对小鼠细胞具有感染性）和异嗜性（即对异源物种的细胞具有感染性但对小鼠细胞没有感染性）。此外，已经清楚的是，MuLV 主要通过小鼠基因组携带的内源病毒位点的垂直传播，而不是通过感染性病毒的水平传播来维持在小鼠群体中。这些病毒基因座由完整和部分病毒基因组组成，其表达可以导致感染性病毒的产生或在没有病毒复制的情况下合成病毒基因产物。人们付出了大量的努力来表征小鼠中存在的 MuLV 的所有成分，并鉴定影响复杂的病毒-宿主相互作用的因素，从而控制它们在体内的表达（综述参见 LillyandPincus1973；OldandStockert1977；Jolicoeur1979）。这些研究的一个成果是 Hartley 和他的同事 (1977) 鉴定出了 Gross 在他的早期实验中分析过的一类特殊的致白血病 MuLV。
In 1951 Ludwik Gross reported experiments which demonstrated the viral etiology of certain murine leukemias. His work identified the presence of an infectious agent in cell-free extracts of AKR thymomas which could transmit leukemia to C3Hf/Bi mice (Gross1951). Subsequent electron microscopic analysis demonstrated the presence of virus particles with the characteristic type c morphology of murine leukemia virus in both preparations of AKR thymomas and of leukemias induced in C3Hf/Bi mice by Gross’ protocol (DmochowskiandGrey1957;Bernhard1960). In the ensuing 30 years it has become obvious that the murine leukemia viruses (MuLV) are a polymorphic family of infectious agents, heterogeneous in their ability to induce disease in mice and even in their ability to infect and replicate in mouse cells (for review seeStephenson1980). Host range classes of MuLV have been defined that are ecotropic, i.e., infectious for mouse cells, and xenotropic, i.e., infectious for cells of heterologous species but not for mouse cells. In addition, it has become clear that MuLV are maintained in the murine population predominantly via vertical transmission of endogenous viral loci carried by the mouse genome, rather than by horizontal transmission of infectious virus. These viral loci consist of complete and partial viral genomes, the expression of which can result in production of infectious virus or in synthesis of viral gene products in the absence of virus replication. A great deal of effort has been directed toward characterization of the repertoire of MuLV that exists in the mouse, and toward identification of the factors which influence the complex virus-host interaction which governs their expression in vivo (for review seeLillyandPincus1973;OldandStockert1977;Jolicoeur1979). One outcome of these investigations has been the identification byHartleyand co-workers (1977) of the particular class of leukemogenic MuLV which Gross assayed in his early experiments.
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脾病灶形成病毒的 env 基因缺乏 p15(E) 决定簇的表达。
影响因子：
3.7
作者：
A. Schultz;S. Ruscetti;E. Scolnick;S. Oroszlan
通讯作者：
S. Oroszlan
AKR Mink细胞诱导病毒在AKR X NFS杂交中诱导淋巴瘤的遗传研究。
影响因子：
15.3
作者：
Cloyd, M W;Hartley, J W;Rowe, W P
通讯作者：
Rowe, W P
影响因子：
3.7
作者：
Kaplan,PL;Topp,WC;Ozanne,B
通讯作者：
Ozanne,B
通过总代的白血病发生鼠白血病病毒：在转化细胞中表达具有重组env基因的病毒。
DOI：
10.1073/pnas.79.12.3872
发表时间：
1982
影响因子：
11.1
作者：
Famulari,NG;Koehne,CF;O'Donnell,PV
通讯作者：
O'Donnell,PV
脾病灶形成病毒Friend株转化产物分析
影响因子：
5.4
作者：
M. Barbacid;D. Troxler;E. Scolnick;S. Aaronson
通讯作者：
S. Aaronson