Maternal resveratrol regulates the growth performance, antioxidant capacity, and intestinal health of suckling piglets through intestinal microorganisms at high summer temperatures.
Maternal resveratrol regulates the growth performance, antioxidant capacity, and intestinal health of suckling piglets through intestinal microorganisms at high summer temperatures.
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夏季高温下母体白藜芦醇通过肠道微生物调节哺乳仔猪的生长性能、抗氧化能力和肠道健康
DOI：
10.3389/fnut.2022.971496
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发表时间：
2022
影响因子：
5
通讯作者：
Xiao, Hao
中科院分区：
文献类型：
--
作者：
Zhao, Yi;Huang, Yujian;Gao, Kaiguo;Wen, Xiaolu;Hu, Shenglan;Wang, Li;Jiang, Zongyong;Xiao, Hao
背景白藜芦醇具有许多有益的特性，包括抗氧化、抗炎和免疫调节特性。中国南方夏季高温影响母猪的繁殖性能。本研究旨在探讨不同热环境条件下日粮中添加白藜芦醇对妊娠后期和哺乳期母猪和仔猪繁殖性能、抗氧化能力、免疫功能和肠道微生物的影响及其与初乳免疫球蛋白的关系。方法对40头健康经产母猪进行两阶段试验。在第一阶段试验中，20头母猪在中等温度环境中使用，在第二阶段试验中，其余20头母猪在高温环境中使用。在这两个阶段中，母猪从妊娠第75天开始饲喂对照饮食或由对照饮食和300 mg/kg白藜芦醇组成的饮食。收集血浆、乳汁和粪便样品，以获得抗氧化能力、免疫功能和肠道微生物的指标。结果与对照组相比，添加白藜芦醇组第一、第二阶段的活产数分别增加了13.24%和26.79%。在第二阶段，白藜芦醇补充增加断奶窝重和生长激素（GH），胰岛素（INS），孕酮（PROG），甘油三酯和尿酸（UA）的浓度。白藜芦醇组妊娠第110天和哺乳第14天的血浆超氧化物歧化酶（SOD）水平以及第一阶段哺乳第14天的谷胱甘肽过氧化物酶（GSH-Px）水平与对照组相比呈上升趋势（分别为p = 0.0728、p = 0.0932和p = 0.067）。在泌乳第14天，白藜芦醇组的血浆总抗氧化能力（T-AOC）水平在第二阶段较高，而血浆丙二醛（MDA）水平在两个阶段均较低。白藜芦醇的补充增加了丰富的免疫球蛋白A（伊加），免疫球蛋白G（IgG），免疫球蛋白M（IgM）的初乳和相对丰富的乳杆菌和Alloprevotella，但减少了相对丰富的土方肠志贺菌在仔猪粪便中的第二阶段。斯皮尔曼相关分析表明，断奶仔猪的增重与初乳中IgM含量和第二阶段仔猪粪便中乳酸菌的丰度呈正相关（p < 0.05）。初乳中异普雷沃菌的丰度与伊加和IgG含量呈正相关，乳杆菌的丰度与IgM含量呈正相关。结论母体添加白藜芦醇可提高高温环境下仔猪的生长性能、抗氧化能力和肠道健康，其机制可能与提高初乳中免疫球蛋白的分泌有关。
Background Resveratrol has numerous beneficial properties, including antioxidant, anti-inflammatory, and immunomodulatory properties. High summer temperatures in Southern China affect the reproductive performance of sows. The present study aimed to investigate the effects of dietary resveratrol supplementation in different thermal environments on the reproductive performance, antioxidant capacity, immune function, and intestinal microbes of sows and piglets during late gestation and lactation, as well as their relationship with colostrum immunoglobulin. Methods A two-phase experiment was conducted with 40 healthy multiparous sows. In the first phase of the experiment, 20 sows were used in a moderate temperature environment, and in the second phase of the experiment, the remaining 20 sows were used in a high-temperature environment. In both phases, sows were fed either a control diet or a diet consists of control diet and 300 mg/kg resveratrol starting on day 75 of gestation. Plasma, milk, and fecal samples were collected to obtain the indices of antioxidant capacity, immune function, and intestinal microbes. Results The results showed that resveratrol supplementation increased the number of live births by 13.24 and 26.79% in the first and second phases, respectively, compared with the control group. In the second phase, resveratrol supplementation increased litter weight at weaning and in the concentrations of growth hormone (GH), insulin (INS), progesterone (PROG), triglycerides, and uric acid (UA). The plasma superoxide dismutase (SOD) level on day 110 of gestation and day 14 of lactation, as well as glutathione peroxidase (GSH-Px) on day 14 of lactation in the first phase, showed an increasing trend (p = 0.0728, p = 0.0932, and p = 0.067, respectively) in the resveratrol group, compared with the control group. On day 14 of lactation, the plasma total antioxidant capability (T-AOC) level was higher in the second phase, while the plasma malondialdehyde (MDA) level was lower in both phases in the resveratrol group. Resveratrol supplementation increased the abundance of immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) in colostrum and the relative abundance of Lactobacillus and Alloprevotella but decreased the relative abundance of Escherichia-shigella in piglet feces in the second phase. In addition, Spearman's correlation analysis indicated that the weight gain of weaned piglets was positively (p < 0.05) associated with IgM content in colostrum and the abundance of Lactobacillus in the fecal microbiota of piglets in the second phase. Moreover, the abundance of Alloprevotella was positively correlated with the contents of IgA and IgG in colostrum, while the abundance of Lactobacillus was positively correlated with IgM content. Conclusion These findings indicated that maternal resveratrol supplementation could enhance the growth performance, antioxidant capacity, and intestinal health of piglets in a high temperature environment, which might be associated with increased immunoglobin secretion from colostrum.
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影响因子：
3.6
作者：
Devillers, N.;Le Dividich, J.;Prunier, A.
通讯作者：
Prunier, A.
影响因子：
3.3
作者：
Mach, Nuria;Berri, Mustapha;Lepage, Patricia
通讯作者：
Lepage, Patricia
影响因子：
3.3
作者：
Bloemhof, S.;Mathur, P. K.;van der Waaij, E. H.
通讯作者：
van der Waaij, E. H.
影响因子：
0.7
作者：
Aydogdu, U.;Guzelbektes, H.
通讯作者：
Guzelbektes, H.
DOI：
10.1017/s1357729800010110
发表时间：
1998-10-01
期刊：
ANIMAL SCIENCE
影响因子：
--
作者：
Kraetzl, WD;Zimmer, C;Schams, D
通讯作者：
Schams, D