Closed loop tracked Doppler optical coherence tomography based heart monitor for the Drosophila melanogaster larvae
Closed loop tracked Doppler optical coherence tomography based heart monitor for the Drosophila melanogaster larvae
复制标题
基于闭环跟踪多普勒光学相干断层扫描的果蝇幼虫心脏监测仪
DOI：
10.1002/jbio.201500007
复制
发表时间：
2016
影响因子：
2.8
通讯作者：
A. Podoleanu
中科院分区：
文献类型：
--
作者：
Mantas Žurauskas;A. Bradu;D. Ferguson;D. Hammer;A. Podoleanu
本文介绍了一种用于研究运动胚胎的新型生物科学仪器。双顺序成像/测量通道通过闭环跟踪架构组装。双通道系统可以在两种情况下工作：(i)单点多普勒信号监测或（ii）快速三维扫描源OCT成像。该系统被证明用于表征黑腹果蝇幼虫的心脏动力学。闭环跟踪可以在没有麻醉或身体约束的情况下对幼虫心脏进行长期的体内监测。这样的仪器可以用来测量心脏行为的细微变化，否则被幼虫的运动所掩盖。连续跟踪一只果蝇幼虫（上），进行连续远程监测。采用基于低相干干涉技术的多普勒传感技术，获得了自由活动幼虫（下）的心跳轨迹。
This paper presents a novel instrument for biosciences, useful for studies of moving embryos. A dual sequential imaging/measurement channel is assembled via a closed‐loop tracking architecture. The dual channel system can operate in two regimes: (i) single‐point Doppler signal monitoring or (ii) fast 3‐D swept source OCT imaging. The system is demonstrated for characterizing cardiac dynamics in Drosophila melanogaster larva. Closed loop tracking enables long term in vivo monitoring of the larvae heart without anesthetic or physical restraint. Such an instrument can be used to measure subtle variations in the cardiac behavior otherwise obscured by the larvae movements. A fruit fly larva (top) was continuously tracked for continuous remote monitoring. A heartbeat trace of freely moving larva (bottom) was obtained by a low coherence interferometry based doppler sensing technique.
登录
查看更多内容
影响因子：
3.8
作者：
Hammer, DX;Ferguson, RD;Schuman, JS
通讯作者：
Schuman, JS
影响因子：
3.6
作者：
Ferguson, RD;Hammer, DX;Schuman, JS
通讯作者：
Schuman, JS
影响因子：
3.5
作者：
Li, Airong;Ahsen, Osman O.;Tanzi, Rudolph E.
通讯作者：
Tanzi, Rudolph E.
影响因子：
4.8
作者：
Ocorr, Karen;Vogler, Georg;Bodmer, Rolf
通讯作者：
Bodmer, Rolf
DOI：
10.1364/josaa.24.001313
发表时间：
2007-05-01
影响因子：
1.9
作者：
Burns, Stephen A.;Tumbar, Remy;Hammer, Daniel X.
通讯作者：
Hammer, Daniel X.