Poly(anhydride) nanoparticles act as effective adjuvants to elicit a persistent immune response
Poly(anhydride) nanoparticles act as effective adjuvants to elicit a persistent immune response
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聚（酸酐）纳米粒子作为有效佐剂来引发持续的免疫反应
DOI：
10.1039/c7ra11891k
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发表时间：
2017-12
期刊：
影响因子：
3.9
通讯作者：
Li Chao
中科院分区：
文献类型：
--
作者：
Liu Caixia;Shen Qiuxai;Zheng Wenwen;Lv Yao;Chen Xinyu;Li Xiaoheng;Zhu Qiqi;Guo Xiaoling;Ge Renshan;Li Chao
为了激发有效的免疫应答以预防和消除传染病和恶性疾病，关键是开发更有效和更安全的疫苗或佐剂以增强天然抗原的抗原性。本研究的目的是制备由聚（甲基乙烯基醚-co-马来酸酐）（PVM/MA）和模型抗原卵清蛋白（OVA）组成的纳米粒，称为p-OVA，以评估抗原的缓释特性和对BALB/c小鼠免疫应答的有效性。结果表明，p-OVAs呈球形，分布均匀，平均粒径约为1.290 nm，体外具有缓释特性。p-OVA免疫BALB/C小鼠后，体内观察到强烈的OVA特异性细胞和体液免疫应答。全血细胞试验和组织学结果也表明，用p-OVA免疫是有效的和相对安全的。总的来说，在这里，我们提供了新的见解，未来的疫苗和/或佐剂设计与PVM/MA，这是有希望的免疫治疗癌症和自身免疫性疾病。
In order to evoke an efficient immune response to prevent and eliminate infectious and malignant diseases, it is critical to develop more effective and safer vaccines or adjuvants to enhance the antigenicity of natural antigens. The objective of this study is to produce nanoparticles composed of poly(methyl vinyl ether-co-maleic anhydride) (PVM/MA) and the model antigen ovalbumin (OVA), termed as p-OVAs, to assess the antigen sustained release property and the effectiveness in the immune responses in BALB/c mice. The results showed that the p-OVAs were spherical, evenly distributed with an average diameter of ∼290 nm, and had a sustained release property in vitro. After immunization of BALB/C mice with p-OVA, strong OVA-specific cellular and humoral immune responses were observed in vivo. The whole blood cell tests and histological results also suggested that immunization with p-OVA is both effective and relatively safe. Overall, here we provide new insight into future vaccine and/or adjuvant design with PVM/MA, which is promising for the immunotherapy of cancer and autoimmune diseases.
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影响因子：
14
作者：
Li, Chao;Liang, Shujing;Cui, Daxiang
通讯作者：
Cui, Daxiang
影响因子：
4.7
作者：
Foster, Suzanne;Duvall, Craig L.;Crownover, Emily F.;Hoffman, Allan S.;Stayton, Patrick S.
通讯作者：
Stayton, Patrick S.
DOI：
10.1016/j.ejpb.2012.06.014
发表时间：
2012-10-01
影响因子：
4.9
作者：
De Souza Reboucas, Juliana;Manuel Irache, Juan;Gamazo, Carlos
通讯作者：
Gamazo, Carlos
影响因子：
19
作者：
Cao, Yuhua;Ma, Yufei;Zhang, Zhijun
通讯作者：
Zhang, Zhijun
影响因子：
--
作者：
I. Tamayo;J. Irache;Cristina Mansilla;Javier Ochoa-Repáraz;J. Lasarte;C. Gamazo
通讯作者：
I. Tamayo;J. Irache;Cristina Mansilla;Javier Ochoa-Repáraz;J. Lasarte;C. Gamazo