Voxelwise and Regional Brain Apparent Diffusion Coefficient Changes on MRI from Birth to 6 Years of Age.
Voxelwise and Regional Brain Apparent Diffusion Coefficient Changes on MRI from Birth to 6 Years of Age.
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DOI：
10.1148/radiol.2020202279
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发表时间：
2021-03
期刊：
影响因子：
19.7
通讯作者：
Ou Y
中科院分区：
文献类型：
--
作者：
Sotardi S;Gollub RL;Bates SV;Weiss R;Murphy SN;Grant PE;Ou Y
了解从0岁到6岁的快速扩散变化的框架在检测神经发育障碍方面很重要。量化0~6岁儿童正常表观弥散系数(ADC)发育模式。对2006年至2013年在某大型学术医院获得的201例健康足月儿童(男108例，年龄范围0-6岁)的年龄别ADC图谱进行分析，以量化四种模式：ADC轨迹、ADC变化率、ADC成熟年龄和成熟年龄的半球不对称性。通过拟合两项指数模型，在全脑、分段区域和体素水平对模式进行了量化。用带Bonferroni校正的t检验评估ADC成熟年龄的半球不对称性。内囊后肢(左侧1.18×10~3μm~2/s；右侧1.17×10~3μm~2/s)、内囊前肢(左侧1.11×10~3μm~2/s；右侧1.09×10~3μm~2/s)、蚯蚓(1.2 6×10~3μm~2/s)、丘脑(左侧1.17×10~3μm~2/s；右侧1.15×10~3μm~2/s)、基底节(左侧1.26×10~3μm~2/s；右侧1.23×10~3μm~2/s)的ADC值较低，提示胎儿期发育较早。ADC的成熟是在1.3至2.4岁之间完成的，具体取决于所在地区。蚯蚓和左侧丘脑最早成熟(1.3岁)。额外侧灰质成熟最晚(右2.3岁；左2.4岁)。ADC成熟较早发生在左侧大脑半球(P<；.001)的几个区域，包括额叶(平均标准差)(左侧2.16岁±0.29岁；右侧2.19岁±0.31岁)、颞叶(左侧1.93岁±0.22岁；右侧1.99岁±0.22岁)和顶叶(左侧1.92岁±0.30岁；右侧2.03岁±0.28岁)白质。成熟早于右侧大脑半球，包括丘脑(左侧1.63岁±0.32岁；右侧1.45岁±0.33岁)、基底节(左侧1.79岁±0.31岁；右侧1.70岁±0.37岁)和海马区(左侧1.93岁±0.34岁；右侧1.78岁±0.33岁)。对0-6岁儿童磁共振弥散加权扫描的标准表观扩散系数发育模式进行量化。这项工作提供了有关大脑早期发育的知识，并可能指导对异常成熟模式的检测。
A framework for understanding rapid diffusion changes from 0 to 6 years of age is important in the detection of neurodevelopmental disorders. To quantify patterns of normal apparent diffusion coefficient (ADC) development from 0 to 6 years of age. Previously constructed age-specific ADC atlases from 201 healthy full-term children (108 male; age range, 0–6 years) with MRI scans acquired from 2006 to 2013 at one large academic hospital were analyzed to quantify four patterns: ADC trajectory, rate of ADC change, age of ADC maturation, and hemispheric asymmetries of maturation ages. Patterns were quantified in whole-brain, segmented regional, and voxelwise levels by fitting a two-term exponential model. Hemispheric asymmetries in ADC maturation ages were assessed using t tests with Bonferroni correction. The posterior limb of the internal capsule (mean ADC: left hemisphere, 1.18 ×103μm2/sec; right hemisphere, 1.17 × 103μm2/sec), anterior limb of the internal capsule (left, 1.11 ×103μm2/sec; right, 1.09 ×103μm2/sec), vermis (1.26 ×103μm2/sec), thalami (left, 1.17 ×103μm2/sec; right, 1.15 ×103μm2/sec), and basal ganglia (left, 1.26 ×103μm2/sec; right, 1.23 ×103μm2/sec) demonstrate low initial ADC values, indicating an earlier prenatal time course of development. ADC maturation was completed between 1.3 and 2.4 years of age, depending on the region. The vermis and left thalamus matured earliest (1.3 years). The frontolateral gray matter matured latest (right, 2.3 years; left, 2.4 years). ADC maturation occurred earlier in the left hemisphere (P < .001) in several regions, including the frontal (mean ± standard deviation) (left, 2.16 years ± 0.29; right, 2.19 years ± 0.31), temporal (left, 1.93 years ± 0.22; right, 1.99 years ± 0.22), and parietal (left, 1.92 years ± 0.30; right, 2.03 years ± 0.28) white matter. Maturation occurred earlier in the right hemisphere (P < .001) in several regions, including the thalami (left, 1.63 years ± 0.32; right, 1.45 years ± 0.33), basal ganglia (left, 1.79 years ± 0.31; right, 1.70 years ± 0.37), and hippocampi (left, 1.93 years ± 0.34; right, 1.78 years ± 0.33). Normative apparent diffusion coefficient developmental patterns on diffusion-weighted MRI scans were quantified in children aged 0 to 6 years. This work provides knowledge about early brain development and may guide the detection of abnormal patterns of maturation.
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发表时间：
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影响因子：
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