Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture.
Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture.
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DOI：
10.1016/j.isci.2022.105595
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发表时间：
2022-12-22
期刊：
影响因子：
5.8
通讯作者：
Toth, Miklos
中科院分区：
文献类型：
--
作者：
Chen, Rosa J.;Nabila, Anika;Phalke, Swati;Castro, Danny Flores;Toth, Judit Gal;Bergin, Paul;Bastiaans, Jeroen;Stuhlmann, Heidi;Pernis, Alessandra B.;Toth, Miklos
5 -羟色胺- 1a受体（5HT1AR）在皮质边缘区高表达，其缺失与焦虑和抑郁有关。5HT1AR杂合敲除（Het）小鼠的类似减少导致焦虑样和应激反应性表型增加。在这里，我们描述了免疫异常在heet女性，其特点是先天和适应性免疫细胞的激活状态。这些雄性仅表现出有限的免疫失调。类似的免疫异常存在于遗传WT雌性（F1）中，而不存在于遗传WT母亲的雄性后代中，这表明性别特异性免疫系统异常依赖于母亲的5HT1AR缺陷，称为母体遗传效应或“遗传养育”。母胎界面的表达谱显示免疫细胞对蜕膜的侵袭减少，滋养细胞迁移加速。这些数据表明，5HT1AR缺陷通过改变母体免疫系统和妊娠中期子宫环境，导致性别偏倚的结果，主要是女性的免疫失调和男性后代的焦虑样行为。5HT1AR是焦虑和抑郁的危险因素5HT1AR与女性免疫系统异常有关，5HT1AR免疫联系是间接的，由于大坝受体缺陷，免疫表型与胎盘发育异常有关；神经科学;转录组
Serotonin-1A receptor (5HT1AR) is highly expressed in corticolimbic regions and its deficit is associated with anxiety and depression. A similar reduction in 5HT1AR heterozygous knockout (Het) mice results in anxiety-like and increased stress-reactivity phenotypes. Here we describe immunological abnormalities in Het females, characterized by an activated state of innate and adaptive immune cells. Het males showed only limited immune dysregulation. Similar immune abnormalities were present in the genetically WT female (F1) but not male offspring of Het mothers, indicating sex-specific immune system abnormalities that are dependent on the mother’s 5HT1AR deficit, known as maternal genetic effect or “genetic nurture”. Expression profiling of the maternal-fetal interface revealed reduced immune cell invasion to decidua and accelerated trophoblast migration. These data suggest that 5HT1AR deficit, by altering the maternal immune system and midgestational in utero environment, leads to sex-biased outcomes, predominantly immune dysregulation in the female and anxiety-like behavior in the male offspring. 5HT1AR is a risk factor in anxiety and depression 5HT1AR is linked to immune system abnormalities in females The 5HT1AR-immunity link is indirect and due to the dam’s receptor deficit The immune phenotype is associated with abnormal placental development Immunology; Neuroscience; Transcriptomics
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影响因子：
3.4
作者：
Garcia-Garcia, Alvaro L.;Newman-Tancredi, Adrian;Leonardo, E. David
通讯作者：
Leonardo, E. David
DOI：
10.1073/pnas.0914805107
发表时间：
2010-04-20
影响因子：
11.1
作者：
Gleason, G.;Liu, B.;Toth, M.
通讯作者：
Toth, M.
DOI：
10.1017/s1461145704004663
发表时间：
2004-12-01
影响因子：
4.8
作者：
Huang, YY;Battistuzzi, C;Mann, JJ
通讯作者：
Mann, JJ
影响因子：
2.7
作者：
Ain, R;Canham, LN;Soares, MJ
通讯作者：
Soares, MJ
影响因子：
3.5
作者：
Howerton, Christopher L.;Bale, Tracy L.
通讯作者：
Bale, Tracy L.