Clinical characteristics and prognosis of ovarian clear cell carcinoma: a 10-year retrospective study.
Clinical characteristics and prognosis of ovarian clear cell carcinoma: a 10-year retrospective study.
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卵巢透明细胞癌的临床特征和预后：10年回顾性研究
DOI：
10.1186/s12885-021-08061-7
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发表时间：
2021-03-25
期刊：
影响因子：
3.8
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Zhu C;Zhu J;Qian L;Liu H;Shen Z;Wu D;Zhao W;Xiao W;Zhou Y
卵巢透明细胞癌是上皮性卵巢癌的一种特殊病理类型。我们进行这项研究是为了调查OCCC的临床特征和结果，并提供额外的支持证据，以帮助临床诊断和管理。这是一项回顾性研究，调查了2010年1月至2020年3月期间在我们中心接受治疗的86例OCCC患者的临床特征和生存结局。还对来自监测、流行病学和最终结果（SEER）癌症登记数据库的179例OCCC患者进行了生存分析。参与者的中位年龄为49.21 ± 9.91岁，其中74.42%在早期诊断。CA 125中位数为601.48 IU/mL，正常者占19.77%。16例（18.60%）患者同时存在子宫内膜异位症，8例（9.3%）患者发生静脉血栓栓塞（VTE）。有5例患者接受了次优细胞减灭术。66例（76.74%）患者接受了淋巴结清扫术，仅3例（4.55%）患者淋巴结阳性。早期诊断患者的3年总生存率（OS）和无进展生存率（PFS）高于晚期OCCC患者。CA 19 -9（P = 0.025）和腹水（P = 0.001）与OS显著相关，而HE 4（P = 0.027）和腹水（P = 0.001）与PFS显著相关。对SEER数据库数据的分析表明，阳性淋巴结也是OS的独立预后因素（P = 0.001）。OCCC通常在早期和年轻时出现，伴有轻度升高的CA 125。CA 19 -9、HE 4、大量腹水、淋巴结阳性是独立的预后因素。在线版本包含补充材料，可通过10.1186/s12885-021-08061-7获得。
Ovarian clear cell carcinoma (OCCC) is a special pathological type of epithelial ovarian carcinoma (EOC). We conducted this research to investigate the clinical characteristics and outcomes of OCCC and to provide additional supporting evidence to aid in the clinical diagnosis and management. This was a retrospective study investigating the clinical characteristics and survival outcomes of 86 patients with OCCC treated at our center between January 2010 and March 2020. Survival analysis was also performed on 179 patients with OCCC obtained from the Surveillance, Epidemiology and End Results (SEER) cancer registry database. The median age of participants was 49.21 ± 9.91 years old, and 74.42% of them were diagnosed at early stage. The median CA125 level was 601.48 IU/mL, while 19.77% of the patients had normal CA125 levels. Sixteen patients (18.60%) had co-existing endometriosis and 8 patients (9.3%) developed venous thromboembolism (VTE). There were 5 patients received suboptimal cytoreduction. Sixty-six patients (76.74%) underwent lymphadenectomy, and only 3 (4.55%) patients had positive lymph nodes. Patients diagnosed at an early stage had higher 3-year overall survival (OS) and progression-free survival (PFS) rates than those with advanced stage OCCC. CA19–9 (P = 0.025) and ascites (P = 0.001) were significantly associated with OS, while HE4 (P = 0.027) and ascites (P = 0.001) were significantly associated with PFS. Analysis of data from the SEER database showed that positive lymph nodes is also an independent prognostic factor for OS (P = 0.001). OCCC often presents at an early stage and young age with a mildly elevated CA125. CA19–9, HE4, massive ascites, and positive lymph node are independent prognostic factors. The online version contains supplementary material available at 10.1186/s12885-021-08061-7.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
DOI：
10.1002/path.4657
发表时间：
2016-01
期刊：
The Journal of pathology
影响因子：
--
作者：
King CM;Barbara C;Prentice A;Brenton JD;Charnock-Jones DS
通讯作者：
Charnock-Jones DS
影响因子：
3.9
作者：
Paik ES;Kim TJ;Choi CH;Kim BG;Bae DS;Lee JW
通讯作者：
Lee JW
影响因子：
4.1
作者：
Kobel, Martin;Piskorz, Anna M;Lee, Sandra;Lui, Shuhong;LePage, Cecile;Marass, Francesco;Rosenfeld, Nitzan;Mes Masson, Anne-Marie;Brenton, James D
通讯作者：
Brenton, James D
卵巢的清晰细胞癌：分子见解和未来的治疗观点。
影响因子：
3.9
作者：
Mabuchi S;Sugiyama T;Kimura T
通讯作者：
Kimura T