Comparison of spontaneous motor pattern generation in non-hemisected and hemisected mouse spinal cord.

Comparison of spontaneous motor pattern generation in non-hemisected and hemisected mouse spinal cord.
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非半切和半切小鼠脊髓自发运动模式生成的比较。

DOI:
10.1016/0304-3940(92)90729-q
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发表时间:
1992
影响因子:
2.5
通讯作者:
Droge,MH
Droge,MH
中科院分区:
医学4区
文献类型:
--
作者:
Tao,Y;Droge,MH

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研究了新生小鼠脊髓后肢外植体腓肠肌 (G) 和胫骨前肌 (TA) 的自发肌电图 (EMG) 模式。与非半切外植体相比,脊髓纵向半切或 L1 半切加横切均未显着改变自发运动节律的发生率。因此,不仅新生儿脊髓的每一半都含有足够的回路来产生运动节律,而且准备越少也同样可能产生这种活动。然而,半切的制剂表现出较慢的节奏,这可能是由于兴奋性连合连接的丧失。节律序列中的周期数与周期周期之间没有发现相关性。在半切和非半切外植体中,G 肌或 TA 肌中出现自发 EMG 节律序列,但不同时出现在两块肌肉中。因此,没有观察到 G 肌和 TA 肌节律爆发之间的周期交替。这种准备中的兴奋性显然不足以维持两块肌肉的激活(无论是周期交替还是共同收缩)。
Spontaneous electromyogram (EMG) patterns in the gastrocnemius (G) and tibialis anterior (TA) muscles of spinal cord-hindlimb explants from neonatal mice were investigated. Compared to non-hemisected explants, neither longitudinal hemisection of the spinal cord nor hemisection plus transection at L1significantly altered the incidence of spontaneous motor rhythm. Therefore, not only does each half of the neonatal spinal cord contain sufficient circuitry to generate motor rhythm, but the more reduced preparations were just as likely to produce such activity. Hemisected preparations, however, exhibited slower rhythm, perhaps due to the loss of excitatory commissural connections. No correlation was found between the number of cycles in a rhythmic sequence and cycle period. In hemisected as well as non-hemisected explants, sequences of spontaneous EMG rhythm occurred in either the G or TA muscle, but not in both muscles simultaneously. Consequently, cycle-to-cycle alternation between rhythmic bursting in the G and TA muscles was not observed. The excitability in such preparations was apparently insufficient for maintained activations of both muscles (either for cycle-to-cycle alternation or for co-contraction).
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