Classification and epidemiology of MCI.
Classification and epidemiology of MCI.
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DOI：
10.1016/j.cger.2013.07.003
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发表时间：
2013-11
影响因子：
3.3
通讯作者：
Knopman DS
中科院分区：
文献类型：
--
作者：
Roberts R;Knopman DS
轻度认知障碍（MCI）是从正常认知到痴呆的中间阶段。尽管对MCI的分类存在争议，但最近公布的MCI标准允许更好地比较MCI的患病率，发病率和结局。MCI受试者在相对较短的时间内进展为痴呆的比率很高。即使在某个时间点恢复正常认知的受试者中，随后发生MCI或痴呆的比率也高于从未发生MCI的受试者。患有MCI的受试者也经历比认知正常的受试者更高的死亡率。更好地表征MCI和了解病情，可能有助于开发更好的诊断机制，包括成像和液体生物标志物，以及开发MCI的治疗和非治疗干预措施。在这篇综述中，我们对MCI的分类、MCI的发病率和患病率的估计、MCI的危险因素以及MCI诊断后的结局进行了概述。
Mild cognitive impairment (MCI) is an intermediate stage in the trajectory from normal cognition to dementia. Despite controversies about the classification of MCI, recent published criteria for MCI allow better comparison of the prevalence, incidence, and outcomes of MCI. Subjects with MCI have a high rate of progression to dementia over a relatively short period. Even among subjects who revert to normal cognition at one point in time, the rate of subsequent MCI or dementia is higher than among those who never develop MCI. Subjects with MCI also experience a greater mortality than cognitively normal subjects. Better characterization of MCI and understanding of the condition, may contribute to development of better diagnostic mechanisms including imaging and fluid biomarkers, and the development of therapeutic, and non-therapeutic interventions for MCI. In this review, we present an overview of the classification of MCI, estimates of the incidence and prevalence of MCI, risk factors for MCI, and the outcomes following an MCI diagnosis.
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影响因子：
7.2
作者：
Ganguli, Mary;Chang, Chung-Chou H.;Lee, Ching-Wen
通讯作者：
Lee, Ching-Wen
影响因子：
9.9
作者：
Fisk, JD;Merry, HR;Rockwood, K
通讯作者：
Rockwood, K
影响因子：
9.9
作者：
Larrieu, S;Letenneur, L;Dartigues, JF
通讯作者：
Dartigues, JF
影响因子：
3.5
作者：
Hänninen, T;Hallikainen, M;Soininen, H
通讯作者：
Soininen, H
影响因子：
--
作者：
Lopez, OL;Jagust, WJ;Kuller, LH
通讯作者：
Kuller, LH