Subjective cognition and mood in persistent chemotherapy-related cognitive impairment.
Subjective cognition and mood in persistent chemotherapy-related cognitive impairment.
复制标题
持续化疗相关认知障碍的主观认知和情绪。
DOI：
10.1007/s11764-021-01055-1
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发表时间：
2022-06
影响因子：
3.7
通讯作者：
Newhouse, Paul A.
中科院分区：
文献类型：
--
作者：
Vega, Jennifer N.;Albert, Kimberly M.;Mayer, Ingrid A.;Taylor, Warren D.;Newhouse, Paul A.
癌症治疗后经常报告持续化疗相关的认知障碍（CRCI），并对生活质量产生负面影响。虽然过去的研究重点关注这种关系背后的潜在病理生理机制，但情绪、压力和焦虑等心理因素在持续性 CRCI 发展中的作用受到的关注较少。作为对一项研究透皮尼古丁贴剂对持续性 CRCI 患者认知表现影响的试验数据的补充分析，我们检查了情绪变化是否与主观和客观认知功能的变化相关。参与者被随机分配接受安慰剂 (n = 11) 或透皮尼古丁 (n = 11) 治疗 6 周，然后停药 2 周，总共 8 周。在治疗前、治疗期间和治疗后的五次访视中，对参与者进行认知功能和情绪的行为、主观和客观测量。尽管我们没有检测到治疗分配对情绪的影响，但在研究过程中，我们观察到情绪测量的显着改善，这与主观和客观认知表现的改善相关。我们观察到客观和主观认知表现测量的改善。这些变化与亚综合征情绪症状的改善有关，这可能是由于参与试验本身所致。这些结果表明，患有持续性 CRCI 的女性可能会受益于对其认知抱怨的支持和验证、癌症后护理中的认知康复/治疗。该研究已在 ClinicalTrials.gov 注册（试验注册号：NCT02312943）。
Persistent chemotherapy-related cognitive impairment (CRCI) is commonly reported following cancer treatment and negatively affects quality of life. While past research has focused on potential pathophysiological mechanisms underlying this relationship, the role of psychological factors, such as mood, stress, and anxiety, in the development of persistent CRCI has received less attention. As an additional analysis of data from a trial investigating the effects of transdermal nicotine patches on cognitive performance in patients with persistent CRCI, we examined whether change in mood was associated with changes in subjective and objective cognitive functioning. Participants were randomized to either placebo (n = 11) or transdermal nicotine (n = 11) for 6 weeks, followed by 2 weeks of treatment withdrawal for a total of 8 weeks. Participants were assessed using behavioral, subjective, and objective measures of cognitive functioning and mood at five visits before, during, and after treatment. Although we did not detect an effect of treatment assignment on mood, over the course of the study, we observed a significant improvement on measures of mood that correlated with improvement in subjective and objective cognitive performance. We observed improvement in objective and subjective cognitive performance measures. These changes were associated with improvement in subsyndromal mood symptoms, likely resulting from participation in the trial itself. These results suggest that women with persistent CRCI may benefit from support and validation of their cognitive complaints, cognitive rehabilitation/therapies into their post-cancer care. The study was registered with clinicaltrials.gov (trial registration: NCT02312943).
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影响因子：
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作者：
Janelsins MC;Kohli S;Mohile SG;Usuki K;Ahles TA;Morrow GR
通讯作者：
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通讯作者：
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