A tale of two connectivities: intra- and inter-subject functional connectivity jointly enable better prediction of social abilities.
A tale of two connectivities: intra- and inter-subject functional connectivity jointly enable better prediction of social abilities.
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DOI：
10.3389/fnins.2022.875828
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发表时间：
2022
影响因子：
4.3
通讯作者：
Redcay, Elizabeth
中科院分区：
文献类型：
--
作者：
Xie, Hua;Redcay, Elizabeth
关键词：
自然主义的功能性磁共振成像（fMRI）模式，如看电影，正吸引越来越多的关注，因为它们能够模拟现实世界对注意力和多模态感觉整合的认知需求。此外，自然主义范式允许以无模型的方式使用主体间功能连接（ISFC）来表征与动态社会认知相关的大脑网络反应。被试内部功能连接（FC）表征了个体的大脑功能结构，而被试内部功能连接（ISFC）表征了个体间由时间锁定的外部动态刺激驱动的神经耦合。在这里，我们假设ISFC和FC提供了关于社会认知个体差异的不同和互补的信息。为了验证这一假设，我们检查了32名健康成年人和90名正常发育儿童的公共观影fMRI数据集。我们建立了三个偏最小二乘回归（PLS）模型来预测使用FC和/或ISFC的社会认知能力，并比较了预测性能，以确定结合两种连通性测量是否可以提高由心理理论（ToM）评估测量的个体社会认知能力的预测准确性。结果表明，ISFC + FC联合模型对个体社会认知能力的预测准确率最高（rho = 0.34, p < 0.001）。我们还证实了精度的提高不是由于特征维数的增加。总之，我们证明了主体内/主体间的连接编码了关于社会能力的独特信息，联合调查可以帮助我们更全面地了解支持社会认知的复杂过程。
Naturalistic functional magnetic resonance imaging (fMRI) paradigms, such as movie viewing, are attracting increased attention, given their ability to mimic the real-world cognitive demands on attention and multimodal sensory integration. Moreover, naturalistic paradigms allow for characterizing brain network responses associated with dynamic social cognition in a model-free manner using inter-subject functional connectivity (ISFC). While intra-subject functional connectivity (FC) characterizes the individual’s brain functional architecture, ISFC characterizes the neural coupling driven by time-locked extrinsic dynamic stimuli across individuals. Here, we hypothesized that ISFC and FC provide distinct and complementary information about individual differences in social cognition. To test this hypothesis, we examined a public movie-viewing fMRI dataset with 32 healthy adults and 90 typically developing children. Building three partial least squares regression (PLS) models to predict social abilities using FC and/or ISFC, we compared predictive performance to determine whether combining two connectivity measures could improve the prediction accuracy of individuals’ social-cognitive abilities measured by a Theory of Mind (ToM) assessment. Our results indicated that the joint model (ISFC + FC) yielded the highest predictive accuracy and significantly predicted individuals’ social cognitive abilities (rho = 0.34, p < 0.001). We also confirmed that the improved accuracy was not due to the increased feature dimensionality. In conclusion, we demonstrated that intra-/inter-subject connectivity encodes unique information about social abilities, and a joint investigation could help us gain a more complete understanding of the complex processes supporting social cognition.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Gao, Siyuan;Greene, Abigail S.;Scheinost, Dustin
通讯作者：
Scheinost, Dustin
影响因子：
56.9
作者：
Hasson, U;Nir, Y;Malach, R
通讯作者：
Malach, R
影响因子：
10.6
作者：
Bai Y;Gong Y;Bai J;Liu J;Deng HW;Calhoun V;Wang YP
通讯作者：
Wang YP
影响因子：
5.7
作者：
Demirtaş M;Ponce-Alvarez A;Gilson M;Hagmann P;Mantini D;Betti V;Romani GL;Friston K;Corbetta M;Deco G
通讯作者：
Deco G