Topical diquafosol for patients with obstructive meibomian gland dysfunction.
Topical diquafosol for patients with obstructive meibomian gland dysfunction.
复制标题
阻塞性巨腺功能障碍患者的局部diquafosol。
DOI：
10.1136/bjophthalmol-2012-302668
复制
发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Amano S
中科院分区：
文献类型：
--
作者：
Arita R;Suehiro J;Haraguchi T;Maeda S;Maeda K;Tokoro H;Amano S
目的通过泪膜参数评价地夸磷索治疗睑板腺功能障碍（MGD）的疗效，并对睑板腺形态进行定量分析。研究对象为10例19眼阻塞性MGD患者。所有受试者均接受3%地夸磷索滴眼液，说明书上注明每日4次，每次1滴。眼部症状评分为0 - 14分。眼睑边缘异常评分为0 - 4分。使用非接触式睑板造影术（meiboscore）对睑板腺的变化进行评分。浅层点状角膜病变（SPK）评分为0 - 3分。Meibum评分为0 - 3级。泪膜的产生通过Schirmer试验进行评价。使用原始软件对睑板腺进行定量图像分析。10例患者完成了4个月以上的治疗。 眼部症状、眼睑边缘异常、SPK评分和睑脂分级均降低。泪膜破裂时间和泪膜弯月面增加。治疗后睑板腺面积的平均比值显著增加（p<0.0001）。定量图像分析可用于评价睑板腺的形态学变化。局部地夸磷索治疗对梗阻性MGD患者有效。
To evaluate the effect of topical diquafosol in patients with meibomian gland dysfunction (MGD) using tear film parameters and quantitatively analyse the meibomian gland morphology. The subjects were 19 eyes of 10 patients diagnosed with obstructive MGD. All subjects were given 3% diquafosol ophthalmic solution with instructions to use one drop four times a day. Ocular symptoms were scored from 0 to 14. Lid margin abnormalities were scored from 0 to 4. Changes in the meibomian glands were scored using non-contact meibography (meiboscore). Superficial punctate keratopathy (SPK) was scored from 0 to 3. Meibum was graded from 0 to 3. Tear film production was evaluated by Schirmer's test. Quantitative image analysis of the meibomian glands was performed using the original software. 10 patients completed more than 4 months of therapy. Ocular symptoms, lid margin abnormalities, SPK score and meibum grade were decreased. Break-up time and tear film meniscus were increased. Mean ratio of the meibomian gland area was significantly increased after treatment (p<0.0001). Quantitative image analysis was useful for evaluating the morphological changes of the meibomian glands. Topical diquafosol therapy was effective for patients with obstructive MGD.
登录
查看更多内容
Sjogren 综合征患者的睑板腺功能障碍
影响因子：
13.7
作者：
Shimazaki, J;Goto, E;Tsubota, K
通讯作者：
Tsubota, K
影响因子：
1.4
作者：
Ong, BL
通讯作者：
Ong, BL
影响因子：
2.8
作者：
Perry, HD;Doshi-Carnevale, S;Bloom, AH
通讯作者：
Bloom, AH
影响因子：
13.7
作者：
Arita, Reiko;Itoh, Kouzo;Amano, Shiro
通讯作者：
Amano, Shiro
影响因子：
2.8
作者：
MATHERS, WD;SHIELDS, WJ;JESTER, JV
通讯作者：
JESTER, JV