RNA-targeting CRISPR systems from metagenomic discovery to transcriptomic engineering.
RNA-targeting CRISPR systems from metagenomic discovery to transcriptomic engineering.
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以RNA为靶点的CRISPR系统从元基因组发现到转录工程。
DOI:
10.1038/s41556-019-0454-7
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发表时间:
2020-02
影响因子:
21.3
通讯作者:
Yeo GW
中科院分区:
文献类型:
--
作者:
Smargon AA;Shi YJ;Yeo GW
Deployment of RNA-guided DNA endonuclease CRISPR-Cas technology has led to radical advances in biology. As the functional diversity of CRISPR-Cas and parallel systems is further explored, RNA manipulation is emerging as a powerful mode of CRISPR-based engineering. In this Perspective, we chart progress in the RNA-targeting CRISPR-Cas (RCas) field and illustrate how continuing evolution in scientific discovery translates into applications for RNA biology and insights into mysteries, obstacles, and alternative technologies that lie ahead.
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影响因子:
16.1
作者:
Chen, Xiaoying;Zaro, Jennica L.;Shen, Wei-Chiang
通讯作者:
Shen, Wei-Chiang
DOI:
10.1126/science.aaf5573
发表时间:
2016-08-05
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
Abudayyeh OO;Gootenberg JS;Konermann S;Joung J;Slaymaker IM;Cox DB;Shmakov S;Makarova KS;Semenova E;Minakhin L;Severinov K;Regev A;Lander ES;Koonin EV;Zhang F
通讯作者:
Zhang F
影响因子:
64.8
作者:
East-Seletsky A;O'Connell MR;Knight SC;Burstein D;Cate JH;Tjian R;Doudna JA
通讯作者:
Doudna JA
影响因子:
82.9
作者:
Charlesworth, Carsten T.;Deshpande, Priyanka S.;Porteus, Matthew H.
通讯作者:
Porteus, Matthew H.
影响因子:
14.8
作者:
Filipovska, Aleksandra;Razif, Muhammad F. M.;Rackham, Oliver
通讯作者:
Rackham, Oliver