Novel oral detoxification of mercury, cadmium, and lead with thiol-modified nanoporous silica.
Novel oral detoxification of mercury, cadmium, and lead with thiol-modified nanoporous silica.
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DOI：
10.1021/am5007707
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发表时间：
2014-04-23
影响因子：
9.5
通讯作者：
Yantasee, Wassana
中科院分区：
文献类型：
--
作者：
Sangvanich, Thanapon;Morry, Jingga;Fox, Cade;Ngamcherdtrakul, Worapol;Goodyear, Shaun;Castro, David;Fryxell, Glen E.;Addleman, Raymond S.;Summers, Anne O.;Yantasee, Wassana
我们开发了一种巯基修饰的纳米多孔二氧化硅材料（SH-SAMMS）作为预防和治疗重金属中毒的口服疗法。据报道，SH-SAMMS在捕获生物液体和水中的重金属方面非常有效。在此，SH-SAMMS在体外和体内动物模型中用于口服解毒重金属的功效和安全性进行了检查。在模拟胃肠液中，SH-SAMMS对甲基汞（MeHg（I））、无机汞（Hg（II））、铅（Pb（II））和镉（Cd（II））具有非常高的亲和力（Kd），并且上级具有羧酸或膦酸配体或市售金属螯合吸附剂的其他SAMMS。SH-SAMMS还能有效去除生物消化鱼组织中的汞，而对鱼体内的大多数营养矿物质没有影响。SH-SAMMS可以将Hg（II）和MeHg（I）紧紧地固定在纳米孔内，从而防止细菌将它们转化为更易吸收的形式。喂食含MeHg（I）、Cd（II）、Pb（II）和SH-SAMMS的饮食2周的大鼠，其血汞水平显著低于仅喂食富含金属的饮食的大鼠。停止富含金属的饮食后，继续服用SH-SAMMS 2周，比不继续口服SH-SAMMS的动物更快、更广泛地清除汞。接受SH-SAMMS的大鼠由于金属暴露而遭受的体重减轻也较少。汞和镉在主要器官中的保留是最低的大鼠喂养与SH-SAMMS在整个四周。SH-SAMMS对血铅有明显的降低作用。SH-SAMMS对肠上皮细胞模型（Caco-2）和常见肠道细菌（大肠杆菌）安全。总之，它作为一种新的口服药物治疗重金属中毒具有很大的潜力。这种新的应用是通过在无毒的纳米多孔材料上安装定制的界面化学来实现的。
We have developed a thiol-modified nanoporous silica material (SH-SAMMS) as an oral therapy for the prevention and treatment of heavy metal poisoning. SH-SAMMS has been reported to be highly efficient at capturing heavy metals in biological fluids and water. Herein, SH-SAMMS was examined for efficacy and safety in both in vitro and in vivo animal models for the oral detoxification of heavy metals. In simulated gastrointestinal fluids, SH-SAMMS had a very high affinity (Kd) for methyl mercury (MeHg(I)), inorganic mercury (Hg(II)), lead (Pb(II)), and cadmium (Cd(II)) and was superior to other SAMMS with carboxylic acid or phosphonic acid ligands or commercially available metal chelating sorbents. SH-SAMMS also effectively removed Hg from biologically digested fish tissue with no effect on most nutritional minerals found in fish. SH-SAMMS could hold Hg(II) and MeHg(I) tightly inside the nanosize pores, thus preventing bacteria from converting them to more absorbable forms. Rats fed a diet containing MeHg(I), Cd(II), and Pb(II) and SH-SAMMS for 2 weeks had blood Hg levels significantly lower than rats fed the metal-rich diet only. Upon cessation of the metal-rich diet, continued administration of SH-SAMMS for 2 weeks facilitated faster and more extensive clearance of Hg than in animals not continued on oral SH-SAMMS. Rats receiving SH-SAMMS also suffered less weight loss as a result of the metal exposure. Retention of Hg and Cd in major organs was lowest in rats fed with SH-SAMMS throughout the entire four weeks. The reduction of blood Pb by SH-SAMMS was significant. SH-SAMMS was safe to intestinal epithelium model (Caco-2) and common intestinal bacteria (Escherichia coli). Altogether, it has great potential as a new oral drug for the treatment of heavy metal poisoning. This new application is enabled by the installation of tailored interfacial chemistry upon nontoxic nanoporous materials.
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影响因子：
11.4
作者：
Chouyyok, Wilaiwan;Shin, Yongsoon;Davidson, Joseph;Samuels, William D.;Lafemina, Nikki H.;Rutledge, Ryan D.;Fryxell, Glen E.;Sangvanich, Thanapon;Yantasee, Wassana
通讯作者：
Yantasee, Wassana
影响因子：
11.4
作者：
Chouyyok, Wilaiwan;Wiacek, Robert J.;Pattamakomsan, Kanda;Sangvanich, Thanapon;Grudzien, Rafal M.;Fryxell, Glen E.;Yantasee, Wassana
通讯作者：
Yantasee, Wassana
影响因子：
10.4
作者：
Clarkson TW
通讯作者：
Clarkson TW
影响因子：
3.5
作者：
Clarkson, Thomas W.;Vyas, Jayesh B.;Ballatorl, Nazzareno
通讯作者：
Ballatorl, Nazzareno
影响因子：
5.8
作者：
Fadda, Hala M.;Merchant, Hamid A.;Basit, Abdul W.
通讯作者：
Basit, Abdul W.