The conception of the ABCD study: From substance use to a broad NIH collaboration.
The conception of the ABCD study: From substance use to a broad NIH collaboration.
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DOI：
10.1016/j.dcn.2017.10.002
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发表时间：
2018-08
影响因子：
4.7
通讯作者：
Weiss SRB
中科院分区：
文献类型：
--
作者：
Volkow ND;Koob GF;Croyle RT;Bianchi DW;Gordon JA;Koroshetz WJ;Pérez-Stable EJ;Riley WT;Bloch MH;Conway K;Deeds BG;Dowling GJ;Grant S;Howlett KD;Matochik JA;Morgan GD;Murray MM;Noronha A;Spong CY;Wargo EM;Warren KR;Weiss SRB
青春期是大脑结构和功能发生巨大变化的时期，青少年的大脑非常容易受到物质使用等经历的影响。然而，关于这些经历如何影响大脑发育，它们如何促进或干扰后来的健康结果，甚至健康的大脑发育是什么样子，我们还需要了解很多。从青少年早期开始的大型纵向研究可以帮助我们了解青少年大脑和认知发展的正常变异性，并梳理出影响它的许多因素，神经影像学、信息学和遗传学技术的最新进展使得进行足够大规模和范围的研究来回答许多悬而未决的问题成为可能。与此同时，美国国立卫生研究院的几个研究所认识到在这样一个项目中合作的价值，因为它能够解决生物，环境和行为因素的作用，如性别，青春期激素，体育参与和社会/经济差异对大脑发育的影响，以及它们与物质使用和精神疾病（包括自杀风险）的出现和发展的关系。因此，青少年大脑认知发展研究旨在回答当今最紧迫的公共卫生问题。
Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use. However, there is much we have yet to learn about how these experiences influence brain development, how they promote or interfere with later health outcomes, or even what healthy brain development looks like. A large longitudinal study beginning in early adolescence could help us understand the normal variability in adolescent brain and cognitive development and tease apart the many factors that influence it. Recent advances in neuroimaging, informatics, and genetics technologies have made it feasible to conduct a study of sufficient size and scope to answer many outstanding questions. At the same time, several Institutes across the NIH recognized the value of collaborating in such a project because of its ability to address the role of biological, environmental, and behavioral factors like gender, pubertal hormones, sports participation, and social/economic disparities on brain development as well as their association with the emergence and progression of substance use and mental illness including suicide risk. Thus, the Adolescent Brain Cognitive Development study was created to answer the most pressing public health questions of our day.
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影响因子：
5.7
作者：
Van Essen, D. C.;Ugurbil, K.;Auerbach, E.;Barch, D.;Behrens, T. E. J.;Bucholz, R.;Chang, A.;Chen, L.;Corbetta, M.;Curtiss, S. W.;Della Penna, S.;Feinberg, D.;Glasser, M. F.;Harel, N.;Heath, A. C.;Larson-Prior, L.;Marcus, D.;Michalareas, G.;Moeller, S.;Oostenveld, R.;Petersen, S. E.;Prior, F.;Schlaggar, B. L.;Smith, S. M.;Snyder, A. Z.;Xu, J.;Yacoub, E.
通讯作者：
Yacoub, E.
影响因子：
3.4
作者：
Brown, Sandra A.;Brumback, T. Y.;Tapert, Susan F.
通讯作者：
Tapert, Susan F.
影响因子：
8
作者：
Barlow, Karen Maria;Crawford, Susan;Dewey, Deborah
通讯作者：
Dewey, Deborah
影响因子：
10.6
作者：
Kessler, RC
通讯作者：
Kessler, RC
影响因子：
2.5
作者：
Somerville, Leah H.;Jones, Rebecca M.;Casey, B. J.
通讯作者：
Casey, B. J.