Prefrontal dopamine and behavioral flexibility: shifting from an "inverted-U" toward a family of functions.
Prefrontal dopamine and behavioral flexibility: shifting from an "inverted-U" toward a family of functions.
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DOI：
10.3389/fnins.2013.00062
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发表时间：
2013
影响因子：
4.3
通讯作者：
Floresco SB
中科院分区：
文献类型：
--
作者：
Floresco SB
对前额皮质（PFC）多巴胺（DA）功能的研究揭示了其在调节多种认知和执行功能中的重要作用。已经出现的一个普遍原则（主要来自工作记忆的研究）是，PFC DA作用于D1受体，按照“倒u”形功能调节认知，因此活动过少或过多都会对表现产生不利影响。然而，当代研究表明，中皮层DA调节行为灵活性不同方面的受体机制在不同的DA受体和认知操作中存在很大差异。本文将回顾精神药理学和神经化学数据，比较和对比内侧PFC中不同DA受体的拮抗和刺激对认知的影响。因此，集合转移依赖于PFC D1和D2受体之间的合作相互作用，然而，这些受体的异常刺激似乎不会对这种功能产生有害影响。另一方面，在涉及奖励不确定性的情况下，成本/收益决策偏差的修正是由PFC D1和D2受体以复杂的、有时相反的方式调节的。从整体上看，这些发现表明，D1受体调节工作记忆的“倒u”型剂量反应曲线并不是一个放之四海而皆准的功能。相反，中脑皮层多巴胺似乎通过一系列功能发挥作用，其中减少或过度的多巴胺活动可以在不同的认知领域产生各种影响。
Studies on prefrontal cortex (PFC) dopamine (DA) function have revealed its essential role in mediating a variety of cognitive and executive functions. A general principle that has emerged (primarily from studies on working memory) is that PFC DA, acting on D1 receptors, regulates cognition in accordance to an “inverted-U” shaped function, so that too little or too much activity has detrimental effects on performance. However, contemporary studies have indicated that the receptor mechanisms through which mesocortical DA regulates different aspects of behavioral flexibility can vary considerably across different DA receptors and cognitive operations. This article will review psychopharmacological and neurochemical data comparing and contrasting the cognitive effects of antagonism and stimulation of different DA receptors in the medial PFC. Thus, set-shifting is dependent on a co-operative interaction between PFC D1 and D2 receptors, yet, supranormal stimulation of these receptors does not appear to have detrimental effects on this function. On the other hand, modification of cost/benefit decision biases in situations involving reward uncertainty is regulated in complex and sometimes opposing ways by PFC D1 vs. D2 receptors. When viewed collectively, these findings suggest that the “inverted-U” shaped dose-response curve underlying D1 receptor modulation of working memory is not a one-size-fits-all function. Rather, it appears that mesocortical DA exerts its effects via a family of functions, wherein reduced or excessive DA activity can have a variety of effects across different cognitive domains.
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影响因子：
2.7
作者：
Druzin, MY;Kurzina, NP;Kozlov, AP
通讯作者：
Kozlov, AP
影响因子：
3.4
作者：
Fletcher, PJ;Tenn, CC;Kapur, S
通讯作者：
Kapur, S
DOI：
10.1523/jneurosci.5835-11.2012
发表时间：
2012-04-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gee S;Ellwood I;Patel T;Luongo F;Deisseroth K;Sohal VS
通讯作者：
Sohal VS
影响因子：
3.4
作者：
GASPAR, P;BLOCH, B;LEMOINE, C
通讯作者：
LEMOINE, C
影响因子：
7.6
作者：
Chudasama, Y;Robbins, TW
通讯作者：
Robbins, TW