Evolution of pathogenicity and sexual reproduction in eight Candida genomes.
Evolution of pathogenicity and sexual reproduction in eight Candida genomes.
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DOI：
10.1038/nature08064
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发表时间：
2009-06-04
期刊：
影响因子：
64.8
通讯作者：
Cuomo, Christina A.
中科院分区：
文献类型：
--
作者：
Butler, Geraldine;Rasmussen, Matthew D.;Lin, Michael F.;Santos, Manuel A. S.;Sakthikumar, Sharadha;Munro, Carol A.;Rheinbay, Esther;Grabherr, Manfred;Forche, Anja;Reedy, Jennifer L.;Agrafioti, Ino;Arnaud, Martha B.;Bates, Steven;Brown, Alistair J. P.;Brunke, Sascha;Costanzo, Maria C.;Fitzpatrick, David A.;de Groot, Piet W. J.;Harris, David;Hoyer, Lois L.;Hube, Bernhard;Klis, Frans M.;Kodira, Chinnappa;Lennard, Nicola;Logue, Mary E.;Martin, Ronny;Neiman, Aaron M.;Nikolaou, Elissavet;Quail, Michael A.;Quinn, Janet;Santos, Maria C.;Schmitzberger, Florian F.;Sherlock, Gavin;Shah, Prachi;Silverstein, Kevin A. T.;Skrzypek, Marek S.;Soll, David;Staggs, Rodney;Stansfield, Ian;Stumpf, Michael P. H.;Sudbery, Peter E.;Srikantha, Thyagarajan;Zeng, Qiandong;Berman, Judith;Berriman, Matthew;Heitman, Joseph;Gow, Neil A. R.;Lorenz, Michael C.;Birren, Bruce W.;Kellis, Manolis;Cuomo, Christina A.
念珠菌属是世界范围内机会性真菌感染的最常见原因。我们报告了六种念珠菌的基因组序列，并比较这些相关的病原体和非病原体。在致病性物种中，细胞壁、分泌和转运基因家族有显著的扩增，表明与毒力相关的适应性。大的基因组束是纯合的三个二倍体物种，可能是由于最近的重组事件。令人惊讶的是，交配和减数分裂途径的关键组成部分在几个物种中缺失。这些包括交配型基因座（MTL）的主要差异;长孢洛德酵母缺乏MTL，其他物种的α 1/α 2细胞身份决定簇的组成部分丢失，引起了关于如何控制交配和细胞类型的问题。对CUG亮氨酸到丝氨酸遗传密码改变的分析表明，99%的祖先CUG密码子被删除，新的密码子在其他地方出现。最后，对C.白色念珠菌基因目录，识别出许多新基因。
Candida species are the most common cause of opportunistic fungal infection worldwide. We report the genome sequences of six Candida species and compare these and related pathogens and nonpathogens. There are significant expansions of cell wall, secreted, and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the Mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/alpha2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine to serine genetic code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the C. albicans gene catalog, identifying many new genes.
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影响因子：
3.1
作者：
Bates, Steven;de la Rosa, Jose M.;Odds, Frank C.
通讯作者：
Odds, Frank C.
影响因子：
64.8
作者：
Dujon, B;Sherman, D;Souciet, JL
通讯作者：
Souciet, JL
影响因子：
3.2
作者：
CHU, WS;MAGEE, BB;MAGEE, PT
通讯作者：
MAGEE, PT
DOI：
10.1073/pnas.0611195104
发表时间：
2007-05-01
影响因子：
11.1
作者：
Kaur, Rupinder;Ma, Biao;Cormack, Brendan P.
通讯作者：
Cormack, Brendan P.
影响因子：
9.4
作者：
Lockhart, Shawn R.;Messer, Shawn A.;Diekema, Daniel J.
通讯作者：
Diekema, Daniel J.