Selenium Nanomaterials to Combat Antimicrobial Resistance.
Selenium Nanomaterials to Combat Antimicrobial Resistance.
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对抗抗菌素耐药性的硒纳米材料。
DOI：
10.3390/molecules26123611
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发表时间：
2021-06-12
期刊：
影响因子：
--
通讯作者：
Rabiee N
中科院分区：
文献类型：
--
作者：
Truong LB;Medina-Cruz D;Mostafavi E;Rabiee N
抗生素耐药性（AMR）的上升作为一种医疗危机，已经导致了巨大的社会和经济影响，其损害对子孙后代构成了重大威胁。目前的治疗方法要么不太有效，要么导致进一步的获得性耐药性。与此同时，几种新的抗菌药物发现方法昂贵、缓慢，并且相对不适合转化为临床世界。因此，纳米材料的使用被认为是一种合适的解决方案。特别是，这篇综述讨论了硒纳米颗粒（SeNPs）作为最有前途的治疗剂之一，在纳米级的基础上，有效地治疗感染。本文综述了硒纳米粒子的合成及其作为抗菌剂的研究进展。虽然物理化学方法产生一致的纳米结构，沿着缩短的加工过程和设计功能化的潜力，但绿色或生物合成代表了快速、廉价、有效和生态友好的方法，具有更大的可调性和多功能性的前景。最后，SeNPs的临床转化面临各种障碍，包括不确定的体内安全性和作用机制以及不明确的监管框架。尽管如此，这些类金属纳米结构所拥有的前景，沿着其他纳米颗粒在治疗细菌感染和减缓AMR危机，值得探索。
The rise of antimicrobial resistance to antibiotics (AMR) as a healthcare crisis has led to a tremendous social and economic impact, whose damage poses a significant threat to future generations. Current treatments either are less effective or result in further acquired resistance. At the same time, several new antimicrobial discovery approaches are expensive, slow, and relatively poorly equipped for translation into the clinical world. Therefore, the use of nanomaterials is presented as a suitable solution. In particular, this review discusses selenium nanoparticles (SeNPs) as one of the most promising therapeutic agents based in the nanoscale to treat infections effectively. This work summarizes the latest advances in the synthesis of SeNPs and their progress as antimicrobial agents using traditional and biogenic approaches. While physiochemical methods produce consistent nanostructures, along with shortened processing procedures and potential for functionalization of designs, green or biogenic synthesis represents a quick, inexpensive, efficient, and eco-friendly approach with more promise for tunability and versatility. In the end, the clinical translation of SeNPs faces various obstacles, including uncertain in vivo safety profiles and mechanisms of action and unclear regulatory frameworks. Nonetheless, the promise possessed by these metalloid nanostructures, along with other nanoparticles in treating bacterial infections and slowing down the AMR crisis, are worth exploring.
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