The QT interval and risk of incident atrial fibrillation.
The QT interval and risk of incident atrial fibrillation.
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DOI：
10.1016/j.hrthm.2013.07.023
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发表时间：
2013-10
期刊：
影响因子：
5.5
通讯作者：
Marcus, Gregory M.
中科院分区：
文献类型：
--
作者：
Mandyam, Mala C.;Soliman, Elsayed Z.;Alonso, Alvaro;Dewland, Thomas A.;Heckbert, Susan R.;Vittinghoff, Eric;Cummings, Steven R.;Ellinor, Patrick T.;Chaitman, Bernard R.;Stocke, Karen;Applegate, William B.;Arking, Dan E.;Butler, Javed;Loehr, Laura R.;Magnani, Jared W.;Murphy, Rachel A.;Satterfield, Suzanne;Newman, Anne B.;Marcus, Gregory M.
Abnormal atrial repolarization is important in the development of atrial fibrillation (AF), but no direct measurement is available in clinical medicine. To determine whether the QT interval, a marker of ventricular repolarization, could be used to predict incident AF. We examined a prolonged QT corrected by the Framingham formula (QTFram) as a predictor of incident AF in the Atherosclerosis Risk in Communities (ARIC) study. The Cardiovascular Health Study (CHS) and Health, Aging, and Body Composition (Health ABC) study were used for validation. Secondary predictors included QT duration as a continuous variable, a short QT interval, and QT intervals corrected by other formulae. Among 14,538 ARIC participants, a prolonged QTFram predicted a roughly two-fold increased risk of AF (hazard ratio [HR] 2.05, 95% confidence interval [CI] 1.42–2.96, p<0.001). No substantive attenuation was observed after adjustment for age, race, sex, study center, body mass index, hypertension, diabetes, coronary disease, and heart failure. The findings were validated in CHS and Health ABC and were similar across various QT correction methods. Also in ARIC, each 10-ms increase in QTFram was associated with an increased unadjusted (HR 1.14, 95%CI 1.10–1.17, p<0.001) and adjusted (HR 1.11, 95%CI 1.07–1.14, p<0.001) risk of AF. Findings regarding a short QT were inconsistent across cohorts. A prolonged QT interval is associated with an increased risk of incident AF.
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影响因子：
24
作者：
Rautaharju, Pentti M.;Surawicz, Borys;Gettes, Leonard S.
通讯作者：
Gettes, Leonard S.
影响因子：
2.8
作者：
FURBERG, CD;PSATY, BM;RAUTAHARJU, PM
通讯作者：
RAUTAHARJU, PM
影响因子：
5.9
作者：
Robbins, J;Nelson, JC;Gottdiener, JS
通讯作者：
Gottdiener, JS
DOI：
10.1111/j.1540-8167.1998.tb00137.x
发表时间：
1998-09-01
影响因子：
2.7
作者：
Satoh, T;Zipes, DP
通讯作者：
Zipes, DP
影响因子：
7.2
作者：
PSATY, BM;LEE, M;LYLES, M
通讯作者：
LYLES, M