Serotonin transporter gene promoter region polymorphism and selective processing of emotional images.
Serotonin transporter gene promoter region polymorphism and selective processing of emotional images.
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DOI：
10.1016/j.biopsycho.2009.08.007
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发表时间：
2010-03
影响因子：
2.6
通讯作者：
McGeary, John E.
中科院分区：
文献类型：
--
作者：
Beevers, Christopher G.;Ellis, Alissa J.;Wells, Tony T.;McGeary, John E.
一些研究已经证明，5-羟色胺转运体启动子区（5-HTTLPR）多态性可以预测情感体验相关脑区对情感图像的神经反应。然而，这种遗传效应的行为后果却鲜为人知。目前的研究使用眼动追踪方法来研究当同时呈现一系列积极和消极的情绪场景时，5-HTTLPR基因型的个体如何分配他们的注意力。短5-HTTLPR等位基因纯合子显示出偏向于关注阳性图像，特别是在30秒试验的前半部分。相比之下，长5-HTTLPR等位基因纯合子看刺激更公平的方式。因此，短5-HTTLPR等位基因纯合子可能试图通过有目的地将其注意力转向正刺激来调节对负刺激的更大反应性。虽然这种敏感性在良性条件下可能有好处，但当将注意力从负面刺激转移所需的认知资源受到损害时，它也可能增加对情感障碍的脆弱性。
Several studies have now documented that the serotonin transporter promoter region (5-HTTLPR) polymorphism predicts neural response to affective images in brain regions involved in the experience of emotion. However, the behavioral consequences of this genetic effect are less well known. The current study used eye-tracking methodology to examine how individuals genotyped for the 5-HTTLPR allocated their attention when simultaneously presented an array of positive and negative emotional scenes. Short 5-HTTLPR allele homozygotes displayed a bias to focus on positive images, particularly in the first half of the 30-second trial. In contrast, long 5-HTTLPR allele homozygotes viewed the stimuli in a more evenhanded fashion. Thus, short 5-HTTLPR allele homozygotes may be attempting to regulate greater reactivity to negative stimuli by purposefully turning their attention towards positive stimuli. Although this sensitivity may have benefits under benign conditions, it may also increase vulnerability to affective disorders when cognitive resources needed to turn attention away from negative stimuli are compromised.
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影响因子：
4.6
作者：
Beevers, Christopher G.;Wells, Tony T.;McGeary, John E.
通讯作者：
McGeary, John E.
影响因子：
4.6
作者：
Beevers, Christopher G.;Gibb, Brandon E.;Miller, Ivan W.
通讯作者：
Miller, Ivan W.
影响因子：
56.9
作者：
Hariri, AR;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
1.8
作者：
KOWLER, E;ANDERSON, E;BLASER, E
通讯作者：
BLASER, E
影响因子：
0.9
作者：
Fiedorowicz, Jess G.;Moser, David J.;Ellingrod, Vicki L.
通讯作者：
Ellingrod, Vicki L.