Maternal caffeine consumption and small for gestational age births: results from a population-based case-control study.
Maternal caffeine consumption and small for gestational age births: results from a population-based case-control study.
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DOI：
10.1007/s10995-013-1397-4
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发表时间：
2014-08
影响因子：
2.3
通讯作者：
National Birth Defects Prevention Study
中科院分区：
文献类型：
--
作者：
Hoyt AT;Browne M;Richardson S;Romitti P;Druschel C;National Birth Defects Prevention Study
咖啡因在怀孕期间以各种形式摄入，在怀孕期间增加了半衰期并穿过胎盘屏障。小于胎龄 (SGA) 是一个重要的围产期结局，并与长期并发症相关。我们利用国家出生缺陷预防研究数据研究了母亲咖啡因摄入量与 SGA 之间的关联。本次分析纳入了预计分娩日期为 1997 年至 2007 年的非畸形活产婴儿 (n = 7,943)。通过总咖啡因摄入量和个别含咖啡因饮料类型（咖啡、茶和苏打水）检查母亲的咖啡因暴露情况；构建性别、种族/民族和胎次特定的生长曲线来估计 SGA 出生率。使用无条件逻辑回归估计粗略比值比和调整比值比 (aOR) 以及 95% 置信区间。评估了母亲吸烟、血管收缩药物的使用和叶酸与咖啡因暴露的相互作用。在此分析中，发现 648 名婴儿 (8.2%) 患有 SGA。观察到总咖啡因摄入量的增加以及每种含咖啡因饮料的 aOR 的增加（根据母亲教育程度、高血压和吸烟情况进行调整），对于最高摄入类别（每种饮料类型每天 300+ 毫克总咖啡因和 3+ 份/天），aOR 范围为 1.3 至 2.1。几乎没有观察到母亲吸烟、使用血管收缩药物或叶酸摄入之间存在累加相互作用。我们观察到，咖啡因摄入量较高的母亲，尤其是每天摄入 300 毫克以上咖啡因的母亲，SGA 出生率会增加。茶摄入量也增加了 aOR，但咖啡和苏打水摄入量的 aOR 更弱。
Caffeine is consumed in various forms during pregnancy, has increased half-life during pregnancy and crosses the placental barrier. Small for gestational age (SGA) is an important perinatal outcome and has been associated with long term complications. We examined the association between maternal caffeine intake and SGA using National Birth Defects Prevention Study data. Non-malformed live born infants with an estimated date of delivery from 1997–2007 (n = 7,943) were included in this analysis. Maternal caffeine exposure was examined as total caffeine intake and individual caffeinated beverage type (coffee, tea, and soda); sex-, race/ethnic-, and parity-specific growth curves were constructed to estimate SGA births. Crude and adjusted odds ratios (aORs) and 95 % confidence intervals were estimated using unconditional logistic regression. Interaction with caffeine exposures was assessed for maternal smoking, vasoconstrictor medication use, and folic acid. Six hundred forty-eight infants (8.2 %) were found to be SGA in this analysis. Increasing aORs were observed for increasing intakes of total caffeine and for each caffeinated beverage with aORs (adjusting for maternal education, high blood pressure, and smoking) ranging from 1.3 to 2.1 for the highest intake categories (300+ mg/day total caffeine and 3+ servings/day for each beverage type). Little indication of additive interaction by maternal smoking, vasoconstrictor medication use, or folic acid intake was observed. We observed an increase in SGA births for mothers with higher caffeine intake, particularly for those consuming 300+ mg of caffeine per day. Increased aORs were also observed for tea intake but were more attenuated for coffee and soda intake.
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DOI：
10.1002/bdra.20365
发表时间：
2007-07-01
影响因子：
--
作者：
Browne, Marilyn L.;Bell, Erin M.;Correa, Adolfo
通讯作者：
Correa, Adolfo
DOI：
10.1159/000457332
发表时间：
1983-01-01
期刊：
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS
影响因子：
--
作者：
BRAZIER, JL;RITTER, J;FAUCON, G
通讯作者：
FAUCON, G
影响因子：
5
作者：
FORTIER, I;MARCOUX, S;BEAULACBAILLARGEON, L
通讯作者：
BEAULACBAILLARGEON, L
影响因子：
3.5
作者：
Grandjean, Philippe;Buclu-Jorgensen, Esben
通讯作者：
Buclu-Jorgensen, Esben
影响因子：
5
作者：
Clausson, B;Granath, F;Cnattingius, S
通讯作者：
Cnattingius, S