The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax.
The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 2.5 and that value by 30% of SUVmax.
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DOI：
10.1007/s11604-022-01378-8
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发表时间：
2023-05
影响因子：
2.1
通讯作者：
Yoshimitsu, Kengo
中科院分区：
文献类型：
--
作者：
Iwasa, Hitomi;Nagamachi, Shigeki;Nakayama, Shizuhide;Yamamoto, Takuaki;Yoshimitsu, Kengo
我们评估了计算基于体积的FDG-PET/CT参数的再现性，即，代谢肿瘤体积（MTV）和总病变糖酵解（TLG），软组织肿瘤。对53例软组织肿瘤进行回顾性分析。确定MTV下限的条件是固定值SUV 2.5或SUVmax的30%。为了研究两名放射科医生测量的一致性，分析了%差异、相关系数和Bland-Altman图。我们比较了这些参数在两个内部和运营商之间的测量协议进行评估。在所有计算的基于体积的参数中，操作员内的%差异值非常好，为0.2- 3.5%。在术者间和术者内分析中，以SUV 2.5固定值作为下限阈值计算的参数的%差异值低于以SUVmax的30%作为下限阈值计算的参数。操作者间MTV30%的相关系数分别为0.84和0.87，低于操作者内评估值。但各参数的相关系数均大于0.84。特别是SUV2.5定值法计算的参数相关系数优于30%SUVmax法。Bland-Altman图分析显示所有参数均具有良好的一致性，尤其是在术中检查中。然而，在操作员间研究中，在每种条件下均观察到一些差异。综上所述，测量软组织肿瘤的基于体积的FDG-PET/CT参数的重现性良好，特别是在操作者内部通过固定下限值SUV 2.5进行测量时。
We evaluated the reproducibility calculating volume-based FDG-PET/CT parameters, i.e., metabolic tumor volume (MTV) and total lesion glycolysis (TLG), in soft tissue tumors. Fifty-three cases with soft tissue tumors were analyzed retrospectively. The conditions determining the lower limit of MTV were fixed value SUV 2.5 or 30% of SUVmax. To investigate the agreement of the measurements by two radiologists, %difference, the correlation coefficients and Bland–Altman plot were analyzed. We compared these parameters in both intra- and inter-operator for evaluating the agreement in the measurements. The values of % difference were excellent, 0.2–3.5%, in the intra-operator in all calculated volume-based parameters. In both inter- and intra-operator analysis, the values of % differences were lower in the parameters calculated by SUV 2.5 fixed value as a lower threshold compared with those calculated by 30% of SUVmax as a lower threshold. The correlation coefficient in MTV30% for inter-operator were 0.84 or 0.87, those were lower than values by the intra-operator evaluation. Nevertheless, the correlation coefficients were higher than 0.84 in every parameter. Particularly, correlation coefficient in the parameters calculated by SUV 2.5 fixed value was better than those calculated by 30% of SUVmax. The Bland–Altman plot analysis showed good agreement for all parameters, particularly in the intra-operator examinations. However, in the inter-operator study, some variances were noted in every condition. In conclusion, the reproducibility of measuring volume-based FDG-PET/CT parameters of soft tissue tumors was good, particularly, in the measurement by fixed lower limit value SUV 2.5 in the intra-operator.
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DOI：
10.3390/life11090869
发表时间：
2021-08-24
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Hack RI;Becker AS;Bode-Lesniewska B;Exner GU;Müller DA;Ferraro DA;Warnock GI;Burger IA;Britschgi C
通讯作者：
Britschgi C
影响因子：
1.6
作者：
Andersen KF;Fuglo HM;Rasmussen SH;Petersen MM;Loft A
通讯作者：
Loft A
软组织肉瘤中基线（18）F-FDG PET/CT的临床值。
影响因子：
1.7
作者：
Reyes Marlés RH;Navarro Fernández JL;Puertas García-Sandoval JP;Santonja Medina F;Mohamed Salem L;Frutos Esteban L;Contreras Gutiérrez JF;Castellón Sánchez MI;Ruiz Merino G;Claver Valderas MA
通讯作者：
Claver Valderas MA
影响因子：
2.6
作者：
Nagamachi, Shigeki;Wakamatsu, Hideyuki;Kawai, Keiichi
通讯作者：
Kawai, Keiichi
影响因子：
--
作者：
Jamet, Bastien;Carlier, Thomas;Rousseau, Caroline
通讯作者：
Rousseau, Caroline