Multidimensional Intersection of Nicotine, Gene Expression, and Behavior.
Multidimensional Intersection of Nicotine, Gene Expression, and Behavior.
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DOI：
10.3389/fnbeh.2021.649129
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发表时间：
2021
影响因子：
3
通讯作者：
Fowler CD
中科院分区：
文献类型：
--
作者：
Sherafat Y;Bautista M;Fowler CD
The cholinergic system plays a crucial role in nervous system function with important effects on developmental processes, cognition, attention, motivation, reward, learning, and memory. Nicotine, the reinforcing component of tobacco and e-cigarettes, directly acts on the cholinergic system by targeting nicotinic acetylcholine receptors (nAChRs) in the brain. Activation of nAChRs leads to a multitude of immediate and long-lasting effects in specific cellular populations, thereby affecting the addictive properties of the drug. In addition to the direct actions of nicotine in binding to and opening nAChRs, the subsequent activation of circuits and downstream signaling cascades leads to a wide range of changes in gene expression, which can subsequently alter further behavioral expression. In this review, we provide an overview of the actions of nicotine that lead to changes in gene expression and further highlight evidence supporting how these changes can often be bidirectional, thereby inducing subsequent changes in behaviors associated with further drug intake.
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影响因子：
2.6
作者：
al'Absi, Mustafa;Lemieux, Andrine;Nakajima, Motohiro;Hatsukami, Dorothy K.;Allen, Sharon
通讯作者：
Allen, Sharon
DOI：
10.1007/7854_2016_467
发表时间：
2018-01-01
期刊：
BEHAVIORAL NEUROSCIENCE OF LEARNING AND MEMORY
影响因子：
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作者：
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通讯作者：
Boccia, M. M.
影响因子：
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作者：
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Zoli, M
影响因子：
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作者：
Chen HY;Cheng FC;Pan HC;Hsu JC;Wang MF
通讯作者：
Wang MF
在子宫内暴露于孕产妇的吸烟与DNA甲基化的改变有关，并且在发育中的胎儿脑中的神经元含量降低。
影响因子：
3.9
作者：
Chatterton Z;Hartley BJ;Seok MH;Mendelev N;Chen S;Milekic M;Rosoklija G;Stankov A;Trencevsja-Ivanovska I;Brennand K;Ge Y;Dwork AJ;Haghighi F
通讯作者：
Haghighi F