Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study.
Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study.
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DOI：
10.5056/jnm.2011.17.3.213
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发表时间：
2011-07
影响因子：
3.4
通讯作者：
Taché Y
中科院分区：
文献类型：
--
作者：
Larauche M;Mulak A;Taché Y
不同的心理、生理或免疫来源的应激源在肠易激综合征的病理生理中起着至关重要的作用，参与症状的发生、临床表现和治疗结果。应用各种急性和慢性外感受性或内感受性应激源的实验应激模型已经发展到动物整个生命周期的不同时期，以评估脆弱性，触发和持续因素，确定应激对内脏敏感性和脑肠轴内相互作用的影响。最近的证据表明，根据动物的年龄、性别、应变差异和特定的方法方面（如对结肠直肠膨胀的内脏运动反应的非侵入性监测），建立适当的实验模型和面对有效性，对于成功识别和评估旨在减少内脏敏感性应激相关改变的新治疗靶点至关重要。应激诱导的内脏疼痛调节的潜在机制涉及基于应激源性质的外周、脊柱和椎管上致敏的组合，以及调节伤害性传递或应激相关镇痛反应的下行通路的失调。
Stressors of different psychological, physical or immune origin play a critical role in the pathophysiology of irritable bowel syndrome participating in symptoms onset, clinical presentation as well as treatment outcome. Experimental stress models applying a variety of acute and chronic exteroceptive or interoceptive stressors have been developed to target different periods throughout the lifespan of animals to assess the vulnerability, the trigger and perpetuating factors determining stress influence on visceral sensitivity and interactions within the brain-gut axis. Recent evidence points towards adequate construct and face validity of experimental models developed with respect to animals' age, sex, strain differences and specific methodological aspects such as non-invasive monitoring of visceromotor response to colorectal distension as being essential in successful identification and evaluation of novel therapeutic targets aimed at reducing stress-related alterations in visceral sensitivity. Underlying mechanisms of stress-induced modulation of visceral pain involve a combination of peripheral, spinal and supraspinal sensitization based on the nature of the stressors and dysregulation of descending pathways that modulate nociceptive transmission or stress-related analgesic response.
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