Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis.
Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis.
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持续药物治疗改变类风湿关节炎的肠道微生物群
DOI：
10.3389/fimmu.2021.704089
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发表时间：
2021
影响因子：
7.3
通讯作者：
Huang R
中科院分区：
文献类型：
--
作者：
Mei L;Yang Z;Zhang X;Liu Z;Wang M;Wu X;Chen X;Huang Q;Huang R
几项研究已经调查了微生物组在类风湿关节炎（RA）发展中的致病作用，但药物治疗期间RA患者肠道微生物组的变化研究较少。本文对22例RA患者随机分为化瘀强肾通痹方（HQT）联合甲氨蝶呤（MTX）治疗组和来氟米特（LEF）联合MTX治疗组，观察两组患者肠道菌群的纵向变化。未经治疗（基线）的RA患者和健康对照之间的肠道微生物组存在差异，RA患者中有37种微生物更丰富，21种微生物（包括Clostridium celatum）含量较低。关于功能分析，维生素K2生物合成与富含RA的细菌相关。此外，在RA患者中，肠道微生物物种的改变似乎通过改变各种肠道微生物组功能途径与RA相关的临床指标相关。进一步观察到两种治疗的临床疗效相似，但两个治疗组中RA相关临床指标的反应趋势不同。例如，HQT治疗影响红细胞沉降率（ESR），而LEF治疗影响C-反应蛋白（CRP）水平。此外，HQT组中有11种物质和9种代谢途径随时间发生显著变化（包括C。celatum，其增加），而在LEF组中，仅4种物质和2种代谢途径随时间显著改变。总之，我们研究了接受HQT或LEF治疗的RA患者肠道微生物组的变化。这些结果为肠道微生物群在RA发病机制中的作用提供了有用的信息，也为开发新的RA治疗方法提供了潜在的有效方向。
Several studies have investigated the causative role of the microbiome in the development of rheumatoid arthritis (RA), but changes in the gut microbiome in RA patients during drug treatment have been less well studied. Here, we tracked the longitudinal changes in gut bacteria in 22 RA patients who were randomized into two groups and treated with Huayu-Qiangshen-Tongbi formula (HQT) plus methotrexate (MTX) or leflunomide (LEF) plus MTX. There were differences in the gut microbiome between untreated (at baseline) RA patients and healthy controls, with 37 species being more abundant in the RA patients and 21 species (including Clostridium celatum) being less abundant. Regarding the functional analysis, vitamin K2 biosynthesis was associated with RA-enriched bacteria. Additionally, in RA patients, alterations in gut microbial species appeared to be associated with RA-related clinical indicators through changing various gut microbiome functional pathways. The clinical efficacy of the two treatments was further observed to be similar, but the response trends of RA-related clinical indices in the two treatment groups differed. For example, HQT treatment affected the erythrocyte sedimentation rate (ESR), while LEF treatment affected the C-reactive protein (CRP) level. Further, 11 species and 9 metabolic pathways significantly changed over time in the HQT group (including C. celatum, which increased), while only 4 species and 2 metabolic pathways significantly changed over time in the LEF group. In summary, we studied the alterations in the gut microbiome of RA patients being treated with HQT or LEF. The results provide useful information on the role of the gut microbiota in the pathogenesis of RA, and they also provide potentially effective directions for developing new RA treatments.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
13.3
作者：
Artacho, Alejandro;Isaac, Sandrine;Scher, Jose U.
通讯作者：
Scher, Jose U.
中药丹参丹参多酚酸盐对耐甲氧西林金黄色葡萄球菌（MRSA）的增强活性
影响因子：
3.5
作者：
Liu, Qing-Qing;Han, Jun;Tang, Hua-Shu
通讯作者：
Tang, Hua-Shu
影响因子：
--
作者：
Kępa M;Miklasińska-Majdanik M;Wojtyczka RD;Idzik D;Korzeniowski K;Smoleń-Dzirba J;Wąsik TJ
通讯作者：
Wąsik TJ
影响因子：
3.9
作者：
Jeong, Yunju;Kim, Ji-Won;Ji, Geun Eog
通讯作者：
Ji, Geun Eog