Probiotics or pro-healers: the role of beneficial bacteria in tissue repair.
Probiotics or pro-healers: the role of beneficial bacteria in tissue repair.
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DOI：
10.1111/wrr.12607
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Pastar I
中科院分区：
文献类型：
--
作者：
Lukic J;Chen V;Strahinic I;Begovic J;Lev-Tov H;Davis SC;Tomic-Canic M;Pastar I
益生菌是有益的微生物，已知对人类健康产生许多积极影响，主要是在对抗病原体方面。益生菌与改善肠溃疡的愈合和感染的皮肤伤口的愈合有关。本文综述了益生菌对肠道上皮和皮肤的促愈合作用的最新发现。益生菌发挥其有益作用的机制包括直接杀死病原体、竞争性置换病原菌、增强上皮屏障、诱导成纤维细胞和上皮细胞的迁移和功能。益生菌的有益免疫调节作用涉及通过诱导产生细胞因子来调节和激活上皮内淋巴细胞、自然杀伤细胞和巨噬细胞。有益细菌的全身效应以及肠道微生物群，免疫系统和皮肤健康之间的联系通过肠道-大脑-皮肤轴进行了讨论。鉴于病原体的抗生素耐药性不断增加，抗生素的使用在治疗皮肤和全身感染方面变得不那么有效。这篇综述指出了有益益生菌作为治疗受伤口愈合障碍和皮肤感染影响的患者的安全替代方法的新视角和治疗潜力。
Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This manuscript reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of intraepithelial lymphocytes, natural killer cells and macrophages through induced production of cytokines. Systemic effects of beneficial bacteria and link between gut microbiota, immune system, and cutaneous health through gut-brain-skin axes are discussed as well. In light of growing antibiotic resistance of pathogens, antibiotic use is becoming less effective in treating cutaneous and systemic infections. This review points to a new perspective and therapeutic potential of beneficial probiotic species as a safe alternative approach for treatment of patients affected by wound healing disorders and cutaneous infections.
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DOI：
10.1074/jbc.m113.502039
发表时间：
2013-10-11
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chen C;Krishnan V;Macon K;Manne K;Narayana SV;Schneewind O
通讯作者：
Schneewind O
影响因子：
8
作者：
通讯作者：
--
影响因子：
6.5
作者：
Di Marzio, L;Cinque, B;Cifone, MG
通讯作者：
Cifone, MG
影响因子：
3.6
作者：
Antikainen, J;Anton, L;Korhonen, TK
通讯作者：
Korhonen, TK
影响因子：
6.4
作者：
Chiba, Yukihide;Shida, Kan;Nomoto, Koji
通讯作者：
Nomoto, Koji