Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats.
Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats.
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DOI：
10.1007/s00213-017-4632-7
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发表时间：
2017-08
影响因子：
3.4
通讯作者：
Fuchs RA
中科院分区：
文献类型：
--
作者：
Arguello AA;Wang R;Lyons CM;Higginbotham JA;Hodges MA;Fuchs RA
环境刺激控制药物复吸需要检索的上下文响应可卡因协会，保持在长期记忆中，通过积极的再巩固过程。从药物成瘾治疗的角度来看，确定这些现象的神经基质是重要的。本研究评估了无颗粒岛叶皮质（AI）是否在药物情境诱导的可卡因寻求行为和可卡因记忆再巩固中发挥作用。大鼠被训练在一个独特的背景下杠杆按压可卡因输注，然后在不同的背景下进行灭绝训练。在实验1中，大鼠在先前可卡因配对的背景下接受双侧微量输注载体或GABA激动剂鸡尾酒（巴氯芬和蝇蕈醇，BM）到AI或上覆的躯体感觉皮层（SSJ，解剖控制区），然后立即进行药物寻求行为（即非加强杠杆按压）的测试。在一个新的背景下，这些操作对自发活动的影响也进行了评估。在实验2中，大鼠在15分钟后再次暴露于可卡因配对的背景下，接受媒介物或BM进入AI，旨在重新激活背景反应可卡因记忆并启动其再巩固。72 h后评估这些操作对药物情境诱导的可卡因寻求行为的影响。BM诱导的AI药理学失活，但不是SSJ，衰减药物上下文诱导的可卡因寻求行为的恢复，而不改变运动活性。相反，记忆再激活后AI失活未能损害随后的药物寻求行为，从而可卡因记忆再巩固。这些发现表明，人工智能是神经回路的一个关键要素，它介导了对可卡因寻求行为的上下文控制。
Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective. The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine-memory reconsolidation. Rats were trained to lever press for cocaine infusions in a distinctive context, followed by extinction training in a different context. Rats in Experiment 1 received bilateral microinfusions of vehicle or a GABA agonist cocktail (baclofen and muscimol, BM) into the AI or the overlying somatosensory cortex (SSJ, anatomical control region) immediately before a test of drug-seeking behavior (i.e. non-reinforced lever presses) in the previously cocaine-paired context. The effects of these manipulations on locomotor activity were also assessed in a novel context. Rats in Experiment 2 received vehicle or BM into the AI after a 15-min re-exposure to the cocaine-paired context, intended to reactivate context-response-cocaine memories and initiate their reconsolidation. The effects of these manipulations on drug context-induced cocaine-seeking behavior were assessed 72 h later. BM-induced pharmacological inactivation of the AI, but not the SSJ, attenuated drug context-induced reinstatement of cocaine-seeking behavior without altering locomotor activity. Conversely, AI inactivation after memory reactivation failed to impair subsequent drug-seeking behavior and thus cocaine-memory reconsolidation. These findings suggest that the AI is a critical element of the neural circuitry that mediates contextual control over cocaine-seeking behavior.
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影响因子：
3.4
作者：
Arguello, Amy A.;Hodges, Matthew A.;Wells, Audrey M.;Lara, Honorio, III;Xie, Xiaohu;Fuchs, Rita A.
通讯作者：
Fuchs, Rita A.
DOI：
10.1111/j.1460-9568.2009.06888.x
发表时间：
2009-09
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Fuchs RA;Bell GH;Ramirez DR;Eaddy JL;Su ZI
通讯作者：
Su ZI
影响因子：
56.9
作者：
Contreras, Marco;Ceric, Francisco;Torrealba, Fernando
通讯作者：
Torrealba, Fernando
影响因子：
10.6
作者：
Franklin, TR;Acton, PD;Childress, AR
通讯作者：
Childress, AR
影响因子：
3.4
作者：
EHRMAN, RN;ROBBINS, SJ;OBRIEN, CP
通讯作者：
OBRIEN, CP