Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition.

Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition.
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肥胖能量学:体重调节和饮食组成的影响。

DOI:
10.1053/j.gastro.2017.01.052
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发表时间:
2017-05
期刊:
影响因子:
29.4
通讯作者:
Guo J
Guo J
中科院分区:
医学1区
文献类型:
--
作者:
Hall KD;Guo J

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体重变化伴随着卡路里摄入和消耗之间的不平衡。这一事实经常被误解为肥胖是由暴食和懒惰引起的,可以通过简单地建议人们少吃多运动来治疗。然而,能量平衡的各个组成部分是动态相关的,体重减轻是通过平衡生理过程来抵制的。虽然低碳水化合物饮食被认为通过增加能量消耗和促进脂肪流失来部分颠覆这些过程,但我们对32项以等卡路里碳水化合物替代脂肪的受控喂养研究进行的荟萃分析发现,低脂肪饮食的能量消耗(26kcal/d;P<0.0001)和脂肪损失(16g/d;P<0.0001)都更大。我们回顾了体重调节的静态、稳定点和设定点模型中能量平衡的组成部分和抵抗体重减轻的作用机制,其中设定点模型与当前数据最相称。
Weight changes are accompanied by imbalances between calorie intake and expenditure. This fact is often misinterpreted to suggest that obesity is caused by gluttony and sloth and can be treated by simply advising people to eat less and move more. However, various components of energy balance are dynamically interrelated and weight loss is resisted by counterbalancing physiological processes. While low-carbohydrate diets have been suggested to partially subvert these processes by increasing energy expenditure and promoting fat loss, our meta-analysis of 32 controlled feeding studies with isocaloric substitution of carbohydrate for fat found that both energy expenditure (26 kcal/d; P <.0001) and fat loss (16 g/d; P <.0001) were greater with lower fat diets. We review the components of energy balance and the mechanisms acting to resist weight loss in the context of static, settling point, and set-point models of body weight regulation, with the set-point model being most commensurate with current data.
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