Amino acid systems in the interpeduncular nucleus are altered in a sex-dependent manner during nicotine withdrawal.
Amino acid systems in the interpeduncular nucleus are altered in a sex-dependent manner during nicotine withdrawal.
复制标题
DOI：
10.1002/jnr.24826
复制
发表时间：
2022-08
影响因子：
4.2
通讯作者：
O'Dell LE
中科院分区：
文献类型：
--
作者：
Carcoba LM;Uribe KP;Ortegon S;Mendez IA;DeBiasi M;O'Dell LE
先前在雄性啮齿动物中的工作确定了内侧缰核-脚间核（MHb-IPN）通路调节尼古丁戒断。具体来说，戒断严重程度与通过释放γ-氨基丁酸（GABA）的中间神经元在IPN中的抑制性张力密切相关。IPN中的抑制性张力由共同释放谷氨酸和乙酰胆碱的MHb的投射调节。在IPN内，抑制性张力也通过控制GABA从局部中间神经元释放的促肾上腺皮质激素释放因子1型（CRF 1）受体进行调节。这项研究扩展了以前的工作，通过比较性别差异的GABA，谷氨酸，以及血清素水平的IPN在尼古丁戒断过程中沉淀。戒断诱导的神经化学效应的性别差异也进行了比较后，全身给药的CRF 1受体拮抗剂。结果显示，IPN中的5-羟色胺水平没有组间差异。一个主要的发现是，女性表现出更大的撤回诱导的GABA水平的增加在IPN比男性。此外，撤回增加IPN谷氨酸水平在女性和男性以类似的方式。与男性相比，CRF 1受体阻滞剂对女性IPN中GABA水平的戒断诱导增加产生了更大的抑制作用，这种作用可能与女性CRF 1受体拮抗剂给药后谷氨酸的强劲增加有关。这些数据表明，氨基酸系统在IPN调制尼古丁戒断的行为影响的性别差异。此外，我们的数据表明，针对压力诱导的IPN激活的药物可能会降低戒断的严重程度，特别是在女性中。
Prior work in male rodents established that the medial habenula-interpeduncular nucleus (MHb-IPN) pathway modulates nicotine withdrawal. Specifically, withdrawal severity has been closely associated with inhibitory tone in the IPN via interneurons that release γ-aminobutyric acid (GABA). Inhibitory tone in the IPN is regulated by projections from the MHb that co-release glutamate and acetylcholine. Within the IPN, inhibitory tone is also regulated via corticotropin-releasing factor type 1 (CRF1) receptors that control GABA release from local interneurons. This study extends previous work by comparing sex differences in GABA, glutamate, as well serotonin levels in the IPN during precipitated nicotine withdrawal. Sex differences in withdrawal-induced neurochemical effects were also compared following systemic administration of a CRF1 receptor antagonist. The results revealed that there were no group differences in serotonin levels in the IPN. A major finding was that females displayed a larger withdrawal-induced increases in GABA levels in the IPN than males. Also, withdrawal increased IPN glutamate levels in a similar manner in females and males. Blockade of CRF1 receptors produced a larger suppression of the withdrawal-induced increases in GABA levels in the IPN of females versus males, an effect that was likely related to the robust increase in glutamate following administration of the CRF1 receptor antagonist in females. These data suggest that amino acid systems in the IPN modulate sex differences in the behavioral effects of nicotine withdrawal. Furthermore, our data imply that medications that target stress-induced activation of the IPN may reduce withdrawal severity, particularly in females.
登录
查看更多内容
影响因子：
2.7
作者：
Skwara, Amanda J.;Karwoski, Tracy E.;Czambel, R. Kenneth;Rubin, Robert T.;Rhodes, Michael E.
通讯作者：
Rhodes, Michael E.
影响因子：
4.7
作者：
McLaughlin I;Dani JA;De Biasi M
通讯作者：
De Biasi M
影响因子：
9.2
作者：
Zhao-Shea, Rubing;Liu, Liwang;Pang, Xueyan;Gardner, Paul D.;Tapper, Andrew R.
通讯作者：
Tapper, Andrew R.
DOI：
10.1016/j.pnpbp.2015.04.005
发表时间：
2016-02-04
影响因子：
5.6
作者：
Torres OV;O'Dell LE
通讯作者：
O'Dell LE
影响因子：
4.7
作者：
Li X;Semenova S;D'Souza MS;Stoker AK;Markou A
通讯作者：
Markou A