Regulation of immune cell trafficking by febrile temperatures

Regulation of immune cell trafficking by febrile temperatures
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发热温度对免疫细胞运输的调节

DOI:
10.1080/02656736.2019.1647357
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发表时间:
2019-11
影响因子:
3.1
通讯作者:
Chen JianFeng
Chen JianFeng
中科院分区:
医学2区
文献类型:
--
作者:
Lin ChangDong;Chen JianFeng

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摘要 发烧是对病原体感染和损伤的复杂生理反应。高温的有益影响之一是刺激免疫细胞运输到淋巴器官和发炎组织,从而增强感染和炎症期间的免疫监视。该运输过程由高度有序的粘附级联组成,包括免疫细胞沿血管壁的束缚和滚动、趋化因子诱导的激活、牢固停滞和血细胞渗出。在这篇综述中,我们总结了目前关于发热温度如何调节免疫细胞运输过程的研究结果。发热温度在关键生物分子的功能调节中发挥着多种作用,这些生物分子参与有序粘附级联的每个步骤,包括 L-选择素、趋化因子以及 α4 和 β2 整合素。更好地了解发热温度诱导的免疫细胞运输调节将为调节免疫力以对抗感染和炎症提供线索。
ABSTRACT Fever is a complex physiological response to pathogen infection and injury. One of the beneficial effects of febrile temperatures is stimulation of immune cell trafficking to the lymphoid organs and inflamed tissues, thereby enhancing immune surveillance during infection and inflammation. This trafficking process consists of a highly ordered adhesion cascade that includes tethering and rolling of immune cells along the vessel walls, chemokine-induced activation, firm arrest and diapedesis. In this review, we summarize the current findings of how febrile temperatures regulate the immune cell trafficking process. Febrile temperatures play multiple roles in the functional regulation of critical biomolecules involved in each step of the ordered adhesion cascade that includes L-selectin, chemokines, and α4 and β2 integrins. A better understanding of febrile temperature-induced regulation of immune cell trafficking will shed light on modulating the immunity to fight against infection and inflammation.
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