Elimination of the error signal in the superior colliculus impairs saccade motor learning.
Elimination of the error signal in the superior colliculus impairs saccade motor learning.
复制标题
DOI：
10.1073/pnas.1806215115
复制
发表时间：
2018-09-18
影响因子：
11.1
通讯作者：
Soetedjo R
中科院分区：
文献类型：
--
作者：
Kojima Y;Soetedjo R
小脑依赖性运动学习理论利用期望运动和实际运动之间的误差来纠正错误的运动。为了支持这一观点，一些研究试图消除小脑的错误信号，并证明学习障碍。然而，这种以前的方法并不成功，因为阻塞误差信号也影响了要学习的运动。在这项研究中，我们选择性地阻止错误信号的扫视适应，一种小脑运动学习，通过灭活错误信号的来源，在上级丘不影响运动学习。眼跳适应受损。因此，我们的研究提供了第一个实验证据，错误信号是小脑运动学习所必需的。当运动变得不对称时，由此产生的运动错误会引起小脑的塑性变化以纠正运动，即，运动适应目前的证据表明，错误信号传递到小脑是由复杂的尖峰起源于下橄榄（IO）。为了证明IO错误信号和运动适应之间的因果关系，一些研究阻止了IO，不幸的是，这不仅影响了适应，而且影响了运动本身。我们通过禁用输入输出的错误信号源来避免这种混淆。一些研究表明，上级丘（SC）作为错误信号的来源，扫视适应IO。当我们去激活SC时，要适应的眼跳的指标不变，但眼跳适应受损。因此，一个完整的吻侧SC是必要的眼跳适应。我们的数据为小脑学习理论提供了实验证据，该理论需要错误信号来驱动运动适应。
Theories of cerebellar-dependent motor learning use the error between the desired and actual movement to correct the erroneous movement. To support this idea, several studies have tried to eliminate the error signal to the cerebellum and demonstrate an impairment of learning. However, such former approaches have not been successful because blocking the error signal also affected the movement to be learned. In this study, we selectively block an error signal for saccade adaptation, a type of cerebellar motor learning, by inactivating the source of the error signal in the superior colliculus without affecting the movement to be learned. Saccade adaptation was impaired. Thus, our study provides the first experimental evidence that an error signal is required for cerebellar motor learning. When movements become dysmetric, the resultant motor error induces a plastic change in the cerebellum to correct the movement, i.e., motor adaptation. Current evidence suggests that the error signal to the cerebellum is delivered by complex spikes originating in the inferior olive (IO). To prove a causal link between the IO error signal and motor adaptation, several studies blocked the IO, which, unfortunately, affected not only the adaptation but also the movement itself. We avoided this confound by inactivating the source of an error signal to the IO. Several studies implicate the superior colliculus (SC) as the source of the error signal to the IO for saccade adaptation. When we inactivated the SC, the metrics of the saccade to be adapted were unchanged, but saccade adaptation was impaired. Thus, an intact rostral SC is necessary for saccade adaptation. Our data provide experimental evidence for the cerebellar learning theory that requires an error signal to drive motor adaptation.
登录
查看更多内容
影响因子：
2.9
作者：
Kojima Y;Soetedjo R;Fuchs AF
通讯作者：
Fuchs AF
影响因子：
2
作者：
Hopp, JJ;Fuchs, AF
通讯作者：
Fuchs, AF
影响因子：
2.5
作者：
HARTING, JK
通讯作者：
HARTING, JK
影响因子：
5.3
作者：
Barash, S;Melikyan, A;Thier, P
通讯作者：
Thier, P
影响因子：
2.9
作者：
COLIN, F;MANIL, J;DESCLIN, JC
通讯作者：
DESCLIN, JC