A local outbreak of dengue caused by an imported case in Dongguan China.
A local outbreak of dengue caused by an imported case in Dongguan China.
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中国东莞发生本土输入性登革热疫情
DOI：
10.1186/1471-2458-12-83
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发表时间：
2012-01-26
影响因子：
4.5
通讯作者：
Chen XG
中科院分区：
文献类型：
--
作者：
Peng HJ;Lai HB;Zhang QL;Xu BY;Zhang H;Liu WH;Zhao W;Zhou YP;Zhong XG;Jiang S;Duan JH;Yan GY;He JF;Chen XG
背景登革热是一种由蚊子传播的发热性病毒性疾病，分布于世界各地的热带和亚热带地区。自1978年广东省首次发现登革热以来，华南地区相继发生了由多角体伊蚊传播的登革热疫情。白纹伊蚊，显示Ae.埃及伊蚊，一种在全世界传播登革热的完全家养病媒。快速和不受控制的城市化是发展中国家的一个特征性变化，对病媒生境、人类生活方式和登革热流行病的传播动态产生了重大影响。2010年9月，在广东省东莞市发现登革热疫情，东莞市的特点是快速城市化。已开始进行调查，以确定原因，描述暴发的化学特征，并实施控制措施以阻止暴发。这是东莞市首次报告登革热暴发疫情，尽管该市以前有登革热病例记录。采用实时荧光定量RT-PCR、病毒cDNA测序、酶联免疫吸附试验（ELISA）等实验室检测方法对病毒感染进行鉴定，并用MEGA 5进行分子系统发育分析。发热监测系统每天报告发热病例。病媒控制措施，包括喷洒杀虫喷雾和消除伊蚊栖息地。结果流行病学调查结果表明，本次登革热疫情是由1例东南亚输入性病例引起的。本次暴发的特点是报告31例，发病率为10万人中的50.63人。白纹伊蚊是引起疫情的唯一病媒物种。病毒cDNA序列分析表明，引起东莞市登革热暴发的病毒为登革病毒血清1型（DENV-1）。白纹伊蚊、白纹伊蚊是造成布雷托指数偏高的主要原因;自建房屋缺乏防蚊设施。这份报告再次肯定了传染病控制监测系统的重要性，并引起了对在城市化地区引起传染病流行的输入性病例的认识。
BackgroundDengue, a mosquito-borne febrile viral disease, is found in tropical and sub-tropical regions around the world. Since the first occurrence of dengue was confirmed in Guangdong, China in 1978, dengue outbreaks have been reported sequentially in different provinces in South China transmitted by.peridomesticAe. albopictusmosquitoes, diplayingAe. aegypti, a fully domestic vector that transmits dengue worldwide. Rapid and uncontrolled urbanization is a characteristic change in developing countries, which impacts greatly on vector habitat, human lifestyle and transmission dynamics on dengue epidemics. In September 2010, an outbreak of dengue was detected in Dongguan, a city in Guangdong province characterized by its fast urbanization. An investigation was initiated to identify the cause, to describe the epidemical characteristics of the outbreak, and to implement control measures to stop the outbreak. This is the first report of dengue outbreak in Dongguan, even though dengue cases were documented before in this city.MethodsEpidemiological data were obtained from local Center of Disease Control and prevention (CDC). Laboratory tests such as real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR), the virus cDNA sequencing, and Enzyme-Linked immunosorbent assay (ELISA) were employed to identify the virus infection and molecular phylogenetic analysis was performed with MEGA5. The febrile cases were reported every day by the fever surveillance system. Vector control measures including insecticidal fogging and elimination of habitats ofAe. albopictuswere used to control the dengue outbreak.ResultsThe epidemiological studies results showed that this dengue outbreak was initiated by an imported case from Southeast Asia. The outbreak was characterized by 31 cases reported with an attack rate of 50.63 out of a population of 100,000.Ae. albopictuswas the only vector species responsible for the outbreak. The virus cDNA sequencing analysis showed that the virus responsible for the outbreak was Dengue Virus serotype-1 (DENV-1).ConclusionsSeveral characterized points of urbanization contributed to this outbreak of dengue in Dongguan: the residents are highly concentrated; the residents' life habits helped to form the habitats ofAe. albopictusand contributed to the high Breteau Index; the self-constructed houses lacks of mosquito prevention facilities. This report has reaffirmed the importance of a surveillance system for infectious diseases control and aroused the awareness of an imported case causing the epidemic of an infectious disease in urbanized region.
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