Development of neonatal brain functional centrality and alterations associated with preterm birth.
Development of neonatal brain functional centrality and alterations associated with preterm birth.
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DOI：
10.1093/cercor/bhac444
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发表时间：
2023-04-25
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影响因子：
--
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在生命早期功能性连接体的形成巩固了未来的学习和行为。然而，我们对大脑区域的功能组织如何在出生后早期成熟为相互连接的枢纽（中心性）的理解是有限的，特别是在应对与不良神经发育结果（如早产）相关的因素方面。我们的特点体素明智的功能中心性（加权程度）在366名新生儿从发展人类连接组项目。我们测试了这一假设，即功能中心性随着足月出生婴儿扫描时的年龄而成熟，并被早产破坏。最后，我们询问了新生儿功能中心性是否可以预测18个月时的一般神经发育结果。我们报告了一个与年龄相关的功能中心性增加，主要是在视觉区域和减少在运动和听觉区域在足月出生的婴儿。早产儿在足月年龄扫描有较高的功能中心性，主要是在视觉区域和运动区域的措施较低。功能中心性与18个月大时的结局无关。因此，早产似乎会影响功能的中心在围产期期间进行实质性发展的地区。我们的工作提出了一个问题，这些改变是适应性的还是破坏性的，它们是否预测了更微妙的神经发育特征，或者在以后的生活中出现。
Formation of the functional connectome in early life underpins future learning and behavior. However, our understanding of how the functional organization of brain regions into interconnected hubs (centrality) matures in the early postnatal period is limited, especially in response to factors associated with adverse neurodevelopmental outcomes such as preterm birth. We characterized voxel-wise functional centrality (weighted degree) in 366 neonates from the Developing Human Connectome Project. We tested the hypothesis that functional centrality matures with age at scan in term-born babies and is disrupted by preterm birth. Finally, we asked whether neonatal functional centrality predicts general neurodevelopmental outcomes at 18 months. We report an age-related increase in functional centrality predominantly within visual regions and a decrease within the motor and auditory regions in term-born infants. Preterm-born infants scanned at term equivalent age had higher functional centrality predominantly within visual regions and lower measures in motor regions. Functional centrality was not related to outcome at 18 months old. Thus, preterm birth appears to affect functional centrality in regions undergoing substantial development during the perinatal period. Our work raises the question of whether these alterations are adaptive or disruptive and whether they predict neurodevelopmental characteristics that are more subtle or emerge later in life.
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影响因子：
4.6
作者：
De Asis-Cruz J;Bouyssi-Kobar M;Evangelou I;Vezina G;Limperopoulos C
通讯作者：
Limperopoulos C
DOI：
10.1111/jcpp.12838
发表时间：
2018-04
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Batalle D;Edwards AD;O'Muircheartaigh J
通讯作者：
O'Muircheartaigh J
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
早产儿大脑连接组学分析揭示功能网络分离的早期发展
影响因子：
3.7
作者：
Cao, Miao;He, Yong;Huang, Hao
通讯作者：
Huang, Hao
影响因子：
3.1
作者：
Broring, Tinka;Oostrom, Kim J.;Oosterlaan, Jaap
通讯作者：
Oosterlaan, Jaap