Depressive symptoms are associated with allostatic load among community-dwelling older adults.
Depressive symptoms are associated with allostatic load among community-dwelling older adults.
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DOI：
10.1016/j.physbeh.2013.10.014
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发表时间：
2014-01-17
影响因子：
2.9
通讯作者：
Moynihan J
中科院分区：
文献类型：
--
作者：
Kobrosly RW;van Wijngaarden E;Seplaki CL;Cory-Slechta DA;Moynihan J
平衡负荷模型已经被用来量化身体对重复应激需求的反应的生理成本，并可能为晚年抑郁症状的各种相关因素提供一个有用的、综合的视角。我们采访了125名纽约州罗切斯特的成年人，年龄从67岁到94岁不等。我们采用等静负荷评分作为衡量下丘脑-垂体-肾上腺轴功能、免疫功能、合成代谢活性和心血管活性的多系统功能障碍的指标。总体而言，使用20个条目的流行病学研究中心抑郁量表计算情感和躯体抑郁症状评分。多元线性回归模型被用来评估不平衡负荷评分与情感性、躯体和整体抑郁症状之间的关系。在我们的平均年龄为76.1岁的样本中，临床显著抑郁症状的一周患病率为12.8%。在调整了人口、社会经济和健康相关因素的模型中，较高的非稳态负荷得分与总体、情感和躯体抑郁症状的得分增加相关：β=1.2 1(95%CI=0.38，2.0 5)；β=0.14(95%CI=0.040，0.2 4)；β=0.60(95%CI=0.2 3，0.97)。我们的结果表明，变态负荷测量与晚年抑郁症状有关。这种关联似乎具有临床意义，因为效应大小的大小与抗抑郁药的使用相当(但方向相反)。未来的研究应该检查变态负荷、心理应激和老年抑郁症状之间的相互关系。
The allostatic load model has been used to quantify the physiological costs of the body’s response to repeated stressful demands and may provide a useful, integrative perspective on the various correlates of late-life depressive symptoms. We interviewed 125 Rochester, NY adults, ranging in age from 67 to 94 years. We employed an allostatic load score as a measure of multisystem dysfunction in hypothalamic-pituitary-adrenal axis function, immune function, anabolic activity, and cardiovascular activity. Overall, affective, and somatic depressive symptom scores were computed using the 20-item Center for Epidemiologic Studies Depression Scale. Multiple linear regression models were used to estimate associations between allostatic load scores and affective, somatic, and overall depressive symptoms. Among our sample of mean age 76.1 years, the one-week prevalence of clinically significant depressive symptoms was 12.8%. In models adjusting for demographic, socioeconomic, and health-related factors, higher allostatic load scores were associated with elevated scores for overall, affective, and somatic depressive symptoms: beta = 1.21 (95% CI = 0.38, 2.05); beta = 0.14 (95% CI = 0.040, 0.24); beta = 0.60 (95% CI = 0.23, 0.97), respectively. Our results suggest that allostatic load measure is associated with late-life depressive symptoms. This association appears to be of clinical significance, as the magnitude of the effect size was comparable (but opposite in direction) to that of antidepressant use. Future research should examine the inter-relationships of allostatic load, psychological stress, and late-life depressive symptoms.
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影响因子：
4.8
作者：
Beluche, Isabelle;Chaudieu, Isabelle;Ancelin, Marie L.
通讯作者：
Ancelin, Marie L.
影响因子：
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作者：
Deverts DJ;Cohen S;DiLillo VG;Lewis CE;Kiefe C;Whooley M;Matthews KA
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Matthews KA
影响因子：
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作者：
Fiske A;Wetherell JL;Gatz M
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Gatz M
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作者：
Balardin, Joana Bisol;Vedana, Gustavo;Bromberg, Elke
通讯作者：
Bromberg, Elke
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15.1
作者：
Chapman, Benjamin P.;van Wijngaarden, Edwin;Moynihan, Jan
通讯作者：
Moynihan, Jan