An Update on the Mutual Impact between SARS-CoV-2 Infection and Gut Microbiota.
An Update on the Mutual Impact between SARS-CoV-2 Infection and Gut Microbiota.
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DOI：
10.3390/v14081774
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发表时间：
2022-08-15
期刊：
影响因子：
--
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中科院分区：
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肠道菌群对身体健康至关重要。研究还表明，肠道微生物群可以调节对呼吸道感染的免疫反应。自2019冠状病毒病大流行爆发以来，越来越多的证据表明，COVID-19的严重程度与肠道微生物群的改变之间存在联系。肠道微生物群的组成可能受到COVID-19的深刻影响，反之亦然。在此，我们总结了SARS-CoV-2感染与肠道微生物群组成相互影响的观察结果。我们讨论了双向相互作用的后果和机制。此外，我们还讨论了SARS-CoV-2与共生细菌之间的免疫交叉反应性，这代表了之前被忽视的COVID-19与共生肠道细菌之间的联系。最后，我们总结了利用微生物干预措施管理COVID-19的进展。
The gut microbiota is essential for good health. It has also been demonstrated that the gut microbiota can regulate immune responses against respiratory tract infections. Since the outbreak of the COVID-19 pandemic, accumulating evidence suggests that there is a link between the severity of COVID-19 and the alteration of one’s gut microbiota. The composition of gut microbiota can be profoundly affected by COVID-19 and vice versa. Here, we summarize the observations of the mutual impact between SARS-CoV-2 infection and gut microbiota composition. We discuss the consequences and mechanisms of the bi-directional interaction. Moreover, we also discuss the immune cross-reactivity between SARS-CoV-2 and commensal bacteria, which represents a previously overlooked connection between COVID-19 and commensal gut bacteria. Finally, we summarize the progress in managing COVID-19 by utilizing microbial interventions.
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DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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