The Role of Schwann Cells in Cancer.

The Role of Schwann Cells in Cancer.
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DOI:
10.1002/adbi.202200089
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发表时间:
2022-09
期刊:
影响因子:
3.7
通讯作者:
Wong, Richard J.
Wong, Richard J.
中科院分区:
生物学3区
文献类型:
--
作者:
Deborde, Sylvie;Wong, Richard J.

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雪旺细胞(SCs)是周围神经系统中最丰富的神经细胞类型,是一个被赋予多种不同功能的亚型家族。SCs促进神经冲动的传递,为神经元提供营养和保护,引导轴突修复神经,调节免疫功能。在癌症的背景下,最近的研究揭示了SCs在促进癌细胞侵袭、调节免疫反应和传递疼痛感觉方面的积极作用。
Schwann cells (SCs) are the most abundant cell type in the nerves in the peripheral nervous system and compose a family of subtypes that are endowed with a variety of different functions. SCs facilitate the transmission of neural impulses, provide nutrients and protection for neurons, guide axons in nerve repair, and regulate immune functions. In the context of cancer, recent studies have revealed an active role of SCs in promoting cancer cell invasion, modulating immune responses, and transmitting pain sensation.
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