Diet and Respiratory Infections: Specific or Generalized Associations?
Diet and Respiratory Infections: Specific or Generalized Associations?
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DOI：
10.3390/nu14061195
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发表时间：
2022-03-11
期刊：
影响因子：
5.9
通讯作者：
Cornelis MC
中科院分区：
文献类型：
--
作者：
Vu TT;Van Horn L;Achenbach CJ;Rydland KJ;Cornelis MC
背景：基于我们最近在英国生物库队列中报道的特定饮食行为与新冠肺炎感染风险之间的关联，我们进一步调查了这些关联是新冠肺炎特有的还是延伸到其他呼吸道感染。方法：从医院和与UKB相关的死亡记录数据中检索肺炎和流感的诊断。基线，自我报告(2006-2010)的饮食行为包括婴儿时期的母乳喂养，以及咖啡、茶、油鱼、加工肉类、红肉(未加工)、水果和蔬菜的摄入量。Logistic回归估计了从基线到2019年12月31日期间肺炎/流感的几率，并根据基线社会人口因素、病史和其他生活方式行为进行了调整。我们考虑了与肺炎、新冠肺炎和咖啡因代谢相关的性别和遗传因素的影响。结果：在470,853名UKB参与者中，4.0%的人在随访期间患有肺炎，0.2%的人患有流感。在基线水平上，咖啡、茶、油性鱼类和水果的消费量增加与未来肺炎事件的风险降低显著且独立相关。食用红肉的增加与显著更高的风险相关。经多变量调整后，每天喝1-3杯咖啡(比1杯)患肺炎的几率(p≤0.001)降低6-9%，每天喝1+杯茶(比1杯/天)患肺炎的几率降低8-11%，在高四分位数食用含油鱼类(比最低四分位数Q1)低10-12%，在高四分位数(比第一季度)食用水果(比第一季度)高9-14%；在第四四分位数(比第一季度)食用红肉高出9%。在流感方面也观察到了类似的关联模式，但只有与茶叶和油性鱼类的关联具有统计学意义。在女性中，水果与肺炎风险之间的关联比男性更强(交互作用的p=0.001)。结论：在英国，咖啡、茶、油性鱼类和水果的消费与肺炎/流感的发生有积极的关联，而红肉的消费与肺炎/流感的发生负相关。咖啡的发现与我们之前报告的新冠肺炎感染的结果相似，而其他发现是针对这些更常见的呼吸道感染的。
Background: Based on our recently reported associations between specific dietary behaviors and the risk of COVID-19 infection in the UK Biobank (UKB) cohort, we further investigate whether these associations are specific to COVID-19 or extend to other respiratory infections. Methods: Pneumonia and influenza diagnoses were retrieved from hospital and death record data linked to the UKB. Baseline, self-reported (2006–2010) dietary behaviors included being breastfed as a baby and intakes of coffee, tea, oily fish, processed meat, red meat (unprocessed), fruit, and vegetables. Logistic regression estimated the odds of pneumonia/influenza from baseline to 31 December 2019 with each dietary component, adjusting for baseline socio-demographic factors, medical history, and other lifestyle behaviors. We considered effect modification by sex and genetic factors related to pneumonia, COVID-19, and caffeine metabolism. Results: Of 470,853 UKB participants, 4.0% had pneumonia and 0.2% had influenza during follow up. Increased consumption of coffee, tea, oily fish, and fruit at baseline were significantly and independently associated with a lower risk of future pneumonia events. Increased consumption of red meat was associated with a significantly higher risk. After multivariable adjustment, the odds of pneumonia (p ≤ 0.001 for all) were lower by 6–9% when consuming 1–3 cups of coffee/day (vs. <1 cup/day), 8–11% when consuming 1+ cups of tea/day (vs. <1 cup/day), 10–12% when consuming oily fish in higher quartiles (vs. the lowest quartile—Q1), and 9–14% when consuming fruit in higher quartiles (vs. Q1); it was 9% higher when consuming red meat in the fourth quartile (vs. Q1). Similar patterns of associations were observed for influenza but only associations with tea and oily fish met statistical significance. The association between fruit and pneumonia risk was stronger in women than in men (p = 0.001 for interaction). Conclusions: In the UKB, consumption of coffee, tea, oily fish, and fruit were favorably associated with incident pneumonia/influenza and red meat was adversely associated. Findings for coffee parallel those we reported previously for COVID-19 infection, while other findings are specific to these more common respiratory infections.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
15.3
作者：
Acikalin, Busra;Sanlier, Nevin
通讯作者：
Sanlier, Nevin
影响因子：
0.9
作者：
Campos, Adrian, I;Kho, Pik;Renteria, Miguel E.
通讯作者：
Renteria, Miguel E.
影响因子：
7
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.