Mn-porphyrin conjugated Au nanoshells encapsulating doxorubicin for potential magnetic resonance imaging and light triggered synergistic therapy of cancer.
Mn-porphyrin conjugated Au nanoshells encapsulating doxorubicin for potential magnetic resonance imaging and light triggered synergistic therapy of cancer.
复制标题
锰卟啉共轭金纳米壳封装阿霉素，用于潜在的磁共振成像和光触发癌症协同治疗
作者：
Jing L;Liang X;Li X;Lin L;Yang Y;Yue X;Dai Z
通过在聚乳酸纳米粒子表面包覆阿霉素形成Au纳米壳层，再通过聚乙二醇将Mn卟啉衍生物连接到Au壳层表面，成功制备了治疗诊断剂。由于引入了聚乙二醇，所得到的药剂表现出优异的胶体稳定性和长的血液循环时间。将Mn卟啉接枝到纳米颗粒表面上赋予了极大改善的弛豫率（Mn 3+的r1值为22.18 mM-1 s-1），有利于准确的癌症诊断和定位肿瘤部位，以引导外部近红外（NIR）激光照射用于光热消融肿瘤。体外实验证实，由于Au纳米壳的高近红外光吸收系数，该试剂表现出有效的光热疗和光触发的阿霉素逐步释放行为。体内实验表明，通过这种治疗诊断剂的化疗和光热治疗的组合提供了协同改善的治疗结果，与单独的治疗相比，使其成为一种有前途的癌症治疗方法。因此，这种治疗诊断剂可以被开发为智能和有前途的纳米系统平台，其集成了用于有效对比增强磁共振成像和协同治疗的多种能力。
A theranostic agent was successfully fabricated by the formation of Au nanoshell around poly(lactic acid) nanoparticles entrapping doxorubicin, followed by linking a Mn-porphyrin derivative on the Au shell surface through polyethylene glycol. The resulted agent exhibited excellent colloidal stability and long blood circulation time due to introducing polyethylene glycol. The grafting Mn-porphyrin onto the nanoparticle surface endowed a greatly improved relaxivity (r1 value of 22.18 mM-1s-1 of Mn3+), favorable for accurate cancer diagnosing and locating the tumor site to guide the external near infrared (NIR) laser irradiation for photothermal ablation of tumors. The in vitro experiments confirmed that the agent exhibited an efficient photohyperthermia and a light triggered and stepwise release behavior of doxorubicin due to the high NIR light absorption coefficient of Au nanoshell. The in vivo experiments showed that the combination of chemotherapy and photothermal therapy through such theranostic agent offered a synergistically improved therapeutic outcome compared with either therapy alone, making it a promising approach for cancer therapy. Therefore, such theranostic agent can be developed as a smart and promising nanosystemplatform that integrates multiple capabilities for both effective contrast enhanced magnetic resonance imaging and synergistic therapy.
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影响因子：
17.1
作者：
Jang, Boseung;Park, Jin-Young;Choi, Yongdoo
通讯作者：
Choi, Yongdoo
影响因子：
19
作者：
Chen J;Yang M;Zhang Q;Cho EC;Cobley CM;Kim C;Glaus C;Wang LV;Welch MJ;Xia Y
通讯作者：
Xia Y
影响因子：
17.1
作者：
Park, Huiyul;Yang, Jaemoon;Yoo, Kyung-Hwa
通讯作者：
Yoo, Kyung-Hwa
影响因子：
19
作者：
Ma, Yan;Liang, Xiaolong;Dai, Zhifei
通讯作者：
Dai, Zhifei
影响因子：
10.8
作者：
ASO, Y;YOSHIOKA, S;TERAO, T
通讯作者：
TERAO, T